Real-Time Raman Monitoring of Calcium Phosphate Precipitation in a Semi-Batch Stirred Crystallizer

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Real-Time Raman Monitoring of Calcium Phosphate Precipitation in a Semi-Batch Stirred Crystallizer. / Han, Bing; Louhi-Kultanen, Marjatta.

In: Crystal Growth and Design, Vol. 18, No. 3, 07.03.2018, p. 1622-1628.

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@article{a68bb10bb2c0485887019ea282d97123,
title = "Real-Time Raman Monitoring of Calcium Phosphate Precipitation in a Semi-Batch Stirred Crystallizer",
abstract = "Semi-batch precipitation of calcium monohydrogen phosphate dihydrate (CaHPO4·2H2O; also termed dicalcium phosphate dihydrate, DCPD) from a homogeneous reaction of KH2PO4 and CaCl2 was studied with inline Raman spectroscopy. In the reaction, hydroxyapatite (HAP, Ca5OH(PO4)3) formed first and transferred to DCPD throughout the entire precipitation process. Raman calibration models were created with a series of KH2PO4-NaOH-water solutions. The reliability of the calibration models was validated with offline measurement of phosphate concentration in the mother liquor. Real-time changes in HPO4 2- and H2PO4 - concentration were monitored and predicted. Comprehensive kinetic information was obtained from liquid and solid analysis. It was found that the influence of the mixing rate on the precipitation was not significant, whereas the reactant feeding rate had a remarkable impact.",
author = "Bing Han and Marjatta Louhi-Kultanen",
note = "TARKISTA ONKO T{\"A}M{\"A} AVATTU 2019.",
year = "2018",
month = "3",
day = "7",
doi = "10.1021/acs.cgd.7b01587",
language = "English",
volume = "18",
pages = "1622--1628",
journal = "Crystal Growth and Design",
issn = "1528-7483",
publisher = "AMERICAN CHEMICAL SOCIETY",
number = "3",

}

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TY - JOUR

T1 - Real-Time Raman Monitoring of Calcium Phosphate Precipitation in a Semi-Batch Stirred Crystallizer

AU - Han, Bing

AU - Louhi-Kultanen, Marjatta

N1 - TARKISTA ONKO TÄMÄ AVATTU 2019.

PY - 2018/3/7

Y1 - 2018/3/7

N2 - Semi-batch precipitation of calcium monohydrogen phosphate dihydrate (CaHPO4·2H2O; also termed dicalcium phosphate dihydrate, DCPD) from a homogeneous reaction of KH2PO4 and CaCl2 was studied with inline Raman spectroscopy. In the reaction, hydroxyapatite (HAP, Ca5OH(PO4)3) formed first and transferred to DCPD throughout the entire precipitation process. Raman calibration models were created with a series of KH2PO4-NaOH-water solutions. The reliability of the calibration models was validated with offline measurement of phosphate concentration in the mother liquor. Real-time changes in HPO4 2- and H2PO4 - concentration were monitored and predicted. Comprehensive kinetic information was obtained from liquid and solid analysis. It was found that the influence of the mixing rate on the precipitation was not significant, whereas the reactant feeding rate had a remarkable impact.

AB - Semi-batch precipitation of calcium monohydrogen phosphate dihydrate (CaHPO4·2H2O; also termed dicalcium phosphate dihydrate, DCPD) from a homogeneous reaction of KH2PO4 and CaCl2 was studied with inline Raman spectroscopy. In the reaction, hydroxyapatite (HAP, Ca5OH(PO4)3) formed first and transferred to DCPD throughout the entire precipitation process. Raman calibration models were created with a series of KH2PO4-NaOH-water solutions. The reliability of the calibration models was validated with offline measurement of phosphate concentration in the mother liquor. Real-time changes in HPO4 2- and H2PO4 - concentration were monitored and predicted. Comprehensive kinetic information was obtained from liquid and solid analysis. It was found that the influence of the mixing rate on the precipitation was not significant, whereas the reactant feeding rate had a remarkable impact.

UR - http://www.scopus.com/inward/record.url?scp=85043307587&partnerID=8YFLogxK

U2 - 10.1021/acs.cgd.7b01587

DO - 10.1021/acs.cgd.7b01587

M3 - Article

VL - 18

SP - 1622

EP - 1628

JO - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

IS - 3

ER -

ID: 18511130