PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

MERJA PENTTILÄ,; MARKKU SALOHEIMO,; ANNE KANERVA,; JARI NATUNEN,; ANNE HUUSKONEN,; CHRISTOPHER LANDOWSKI,; JUHANI SAARINEN,; ANN WESTERHOLM-PARVINEN,; ANNA-LIISA HÄNNINEN,; NOORA SALOVUORI,

PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

MERJA PENTTILÄ, (Inventor)
, MARKKU SALOHEIMO, (Inventor)
, ANNE KANERVA, (Inventor)
, JARI NATUNEN, (Inventor)
, ANNE HUUSKONEN, (Inventor)
, CHRISTOPHER LANDOWSKI, (Inventor)
, JUHANI SAARINEN, (Inventor)
, ANN WESTERHOLM-PARVINEN, (Inventor)
, ANNA-LIISA HÄNNINEN, (Inventor)
, NOORA SALOVUORI, (Inventor)

Not published at Aalto University

Novartis

Research output: Patent

Abstract

The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

Original language	English
Patent number	MX2014008272
IPC	C12P 21/ 02 A I
Priority date	04/01/2013
Publication status	Published - 24 Feb 2015
MoE publication type	H1 Granted patent

Cite this

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title = "PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.",

abstract = "The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.",

author = "MERJA PENTTIL{\"A}, and MARKKU SALOHEIMO, and ANNE KANERVA, and JARI NATUNEN, and ANNE HUUSKONEN, and CHRISTOPHER LANDOWSKI, and JUHANI SAARINEN, and ANN WESTERHOLM-PARVINEN, and ANNA-LIISA H{\"A}NNINEN, and NOORA SALOVUORI,",

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language = "English",

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note = "MX2014008272; C12P 21/ 02 A I",

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T1 - PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

AU - PENTTILÄ,, MERJA

AU - SALOHEIMO,, MARKKU

AU - KANERVA,, ANNE

AU - NATUNEN,, JARI

AU - HUUSKONEN,, ANNE

AU - LANDOWSKI,, CHRISTOPHER

AU - SAARINEN,, JUHANI

AU - WESTERHOLM-PARVINEN,, ANN

AU - HÄNNINEN,, ANNA-LIISA

AU - SALOVUORI,, NOORA

PY - 2015/2/24

Y1 - 2015/2/24

N2 - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

AB - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

M3 - Patent

M1 - MX2014008272

ER -

PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

Abstract

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