PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

MERJA PENTTILÄ,; MARKKU SALOHEIMO,; ANNE KANERVA,; JARI NATUNEN,; ANNE HUUSKONEN,; CHRISTOPHER LANDOWSKI,; JUHANI SAARINEN,; ANN WESTERHOLM-PARVINEN,; ANNA-LIISA HÄNNINEN,; NOORA SALOVUORI,

PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

MERJA PENTTILÄ, (Inventor), MARKKU SALOHEIMO, (Inventor), ANNE KANERVA, (Inventor), JARI NATUNEN, (Inventor), ANNE HUUSKONEN, (Inventor), CHRISTOPHER LANDOWSKI, (Inventor), JUHANI SAARINEN, (Inventor), ANN WESTERHOLM-PARVINEN, (Inventor), ANNA-LIISA HÄNNINEN, (Inventor), NOORA SALOVUORI, (Inventor)

Not published at Aalto University

Novartis

Research output: Patent

Abstract

The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

Original language	English
Patent number	MX2014008272
IPC	C12P 21/ 02 A I
Priority date	04/01/2013
Publication status	Published - 24 Feb 2015
MoE publication type	H1 Granted patent

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title = "PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.",

abstract = "The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.",

author = "MERJA PENTTIL{\"A}, and MARKKU SALOHEIMO, and ANNE KANERVA, and JARI NATUNEN, and ANNE HUUSKONEN, and CHRISTOPHER LANDOWSKI, and JUHANI SAARINEN, and ANN WESTERHOLM-PARVINEN, and ANNA-LIISA H{\"A}NNINEN, and NOORA SALOVUORI,",

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language = "English",

type = "Patent",

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TY - PAT

T1 - PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

AU - PENTTILÄ,, MERJA

AU - SALOHEIMO,, MARKKU

AU - KANERVA,, ANNE

AU - NATUNEN,, JARI

AU - HUUSKONEN,, ANNE

AU - LANDOWSKI,, CHRISTOPHER

AU - SAARINEN,, JUHANI

AU - WESTERHOLM-PARVINEN,, ANN

AU - HÄNNINEN,, ANNA-LIISA

AU - SALOVUORI,, NOORA

PY - 2015/2/24

Y1 - 2015/2/24

N2 - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

AB - The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

M3 - Patent

M1 - MX2014008272

ER -

PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

Abstract

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