PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.

MERJA PENTTILÄ, (Inventor), MARKKU SALOHEIMO, (Inventor), ANNE KANERVA, (Inventor), JARI NATUNEN, (Inventor), ANNE HUUSKONEN, (Inventor), CHRISTOPHER LANDOWSKI, (Inventor), JUHANI SAARINEN, (Inventor), ANN WESTERHOLM-PARVINEN, (Inventor), ANNA-LIISA HÄNNINEN, (Inventor), NOORA SALOVUORI, (Inventor)

Research output: Patent

Abstract

The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells, in particular in a filamentous fungal cell comprising at least three endogenous proteases having reduced activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the polypeptide is produced at a level of at least two-fold higher than the production level of the polypeptide in a corresponding parental filamentous fungal cell in which the proteases do not have the reduced activity.

Original languageEnglish
Patent numberMX2014008272
IPCC12P 21/ 02 A I
Priority date04/01/2013
Publication statusPublished - 24 Feb 2015
MoE publication typeH1 Granted patent

Fingerprint Dive into the research topics of 'PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF.'. Together they form a unique fingerprint.

Cite this