Propofol adsorption at the air/water interface: a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study

Research output: Contribution to journalArticleScientificpeer-review

Standard

Propofol adsorption at the air/water interface : a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study. / Niga, Petru; Hansson-Mille, Petra M.; Swerin, Agne; Claesson, Per M.; Schoelkopf, Joachim; Gane, Patrick A.C.; Dai, Jing; Furó, István; Campbell, Richard A.; Johnson, C. Magnus.

In: Soft Matter, Vol. 15, No. 1, 01.01.2019, p. 38-46.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Niga, P, Hansson-Mille, PM, Swerin, A, Claesson, PM, Schoelkopf, J, Gane, PAC, Dai, J, Furó, I, Campbell, RA & Johnson, CM 2019, 'Propofol adsorption at the air/water interface: a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study' Soft Matter, vol. 15, no. 1, pp. 38-46. https://doi.org/10.1039/C8SM01677A

APA

Vancouver

Author

Niga, Petru ; Hansson-Mille, Petra M. ; Swerin, Agne ; Claesson, Per M. ; Schoelkopf, Joachim ; Gane, Patrick A.C. ; Dai, Jing ; Furó, István ; Campbell, Richard A. ; Johnson, C. Magnus. / Propofol adsorption at the air/water interface : a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study. In: Soft Matter. 2019 ; Vol. 15, No. 1. pp. 38-46.

Bibtex - Download

@article{c534099454df46c0aa1ab84db236d783,
title = "Propofol adsorption at the air/water interface: a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study",
abstract = "Propofol is an amphiphilic small molecule that strongly influences the function of cell membranes, yet data regarding interfacial properties of propofol remain scarce. Here we consider propofol adsorption at the air/water interface as elucidated by means of vibrational sum frequency spectroscopy (VSFS), neutron reflectometry (NR), and surface tensiometry. VSFS data show that propofol adsorbed at the air/water interface interacts with water strongly in terms of hydrogen bonding and weakly in the proximity of the hydrocarbon parts of the molecule. In the concentration range studied there is almost no change in the orientation adopted at the interface. Data from NR show that propofol forms a dense monolayer with a thickness of 8.4 {\AA} and a limiting area per molecule of 40 {\AA}2, close to the value extracted from surface tensiometry. The possibility that islands or multilayers of propofol form at the air/water interface is therefore excluded as long as the solubility limit is not exceeded. Additionally, measurements of the 1H NMR chemical shifts demonstrate that propofol does not form dimers or multimers in bulk water up to the solubility limit.",
author = "Petru Niga and Hansson-Mille, {Petra M.} and Agne Swerin and Claesson, {Per M.} and Joachim Schoelkopf and Gane, {Patrick A.C.} and Jing Dai and Istv{\'a}n Fur{\'o} and Campbell, {Richard A.} and Johnson, {C. Magnus}",
year = "2019",
month = "1",
day = "1",
doi = "10.1039/C8SM01677A",
language = "English",
volume = "15",
pages = "38--46",
journal = "Soft Matter",
issn = "1744-683X",
number = "1",

}

RIS - Download

TY - JOUR

T1 - Propofol adsorption at the air/water interface

T2 - a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study

AU - Niga, Petru

AU - Hansson-Mille, Petra M.

AU - Swerin, Agne

AU - Claesson, Per M.

AU - Schoelkopf, Joachim

AU - Gane, Patrick A.C.

AU - Dai, Jing

AU - Furó, István

AU - Campbell, Richard A.

AU - Johnson, C. Magnus

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Propofol is an amphiphilic small molecule that strongly influences the function of cell membranes, yet data regarding interfacial properties of propofol remain scarce. Here we consider propofol adsorption at the air/water interface as elucidated by means of vibrational sum frequency spectroscopy (VSFS), neutron reflectometry (NR), and surface tensiometry. VSFS data show that propofol adsorbed at the air/water interface interacts with water strongly in terms of hydrogen bonding and weakly in the proximity of the hydrocarbon parts of the molecule. In the concentration range studied there is almost no change in the orientation adopted at the interface. Data from NR show that propofol forms a dense monolayer with a thickness of 8.4 Å and a limiting area per molecule of 40 Å2, close to the value extracted from surface tensiometry. The possibility that islands or multilayers of propofol form at the air/water interface is therefore excluded as long as the solubility limit is not exceeded. Additionally, measurements of the 1H NMR chemical shifts demonstrate that propofol does not form dimers or multimers in bulk water up to the solubility limit.

AB - Propofol is an amphiphilic small molecule that strongly influences the function of cell membranes, yet data regarding interfacial properties of propofol remain scarce. Here we consider propofol adsorption at the air/water interface as elucidated by means of vibrational sum frequency spectroscopy (VSFS), neutron reflectometry (NR), and surface tensiometry. VSFS data show that propofol adsorbed at the air/water interface interacts with water strongly in terms of hydrogen bonding and weakly in the proximity of the hydrocarbon parts of the molecule. In the concentration range studied there is almost no change in the orientation adopted at the interface. Data from NR show that propofol forms a dense monolayer with a thickness of 8.4 Å and a limiting area per molecule of 40 Å2, close to the value extracted from surface tensiometry. The possibility that islands or multilayers of propofol form at the air/water interface is therefore excluded as long as the solubility limit is not exceeded. Additionally, measurements of the 1H NMR chemical shifts demonstrate that propofol does not form dimers or multimers in bulk water up to the solubility limit.

UR - http://www.scopus.com/inward/record.url?scp=85058894693&partnerID=8YFLogxK

U2 - 10.1039/C8SM01677A

DO - 10.1039/C8SM01677A

M3 - Article

VL - 15

SP - 38

EP - 46

JO - Soft Matter

JF - Soft Matter

SN - 1744-683X

IS - 1

ER -

ID: 31095847