Production of Fucosylated Glycoproteins

JARI NATUNEN (Inventor), ANN WESTERHOLM-PARVINEN (Inventor), HANNA SALO (Inventor), JUSSI JOENSUU (Inventor), HELI VISKARI (Inventor), CHRISTOPHER LANDOWSKI (Inventor), ANNE HUUSKONEN (Inventor), ANNE KANERVA (Inventor), ANNA-LIISA HANNINEN (Inventor), NOORA SALOVUORI (Inventor), Merja Penttilä (Inventor), JUHANI SAARINEN (Inventor), MARKKU SALOHEIMO (Inventor)

Research output: Patent

Abstract

Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.

Original languageEnglish
Patent numberUS2015176044
IPCC12N 15/ 80 A I
Priority date23/05/2013
Publication statusPublished - 25 Jun 2015
MoE publication typeH1 Granted patent

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    NATUNEN, JARI., WESTERHOLM-PARVINEN, ANN., SALO, HANNA., JOENSUU, JUSSI., VISKARI, HELI., LANDOWSKI, CHRISTOPHER., HUUSKONEN, ANNE., KANERVA, ANNE., HANNINEN, ANNA-LIISA., SALOVUORI, NOORA., Penttilä, M., SAARINEN, JUHANI., & SALOHEIMO, MARKKU. (2015). IPC No. C12N 15/ 80 A I. Production of Fucosylated Glycoproteins. (Patent No. US2015176044).