In the present investigation, dissimilar Al-SS friction welding of pipe joint configuration with an outer diameter of 88.90 mm and a wall thickness of 5.4 mm was performed. Four different experimental conditions were varied based on visual inspection after each weld. The welded pipe joints were evaluated by vacuum leak detection, thermal shock test, pneumatic pressure test, tensile test, optical and scanning electron microscopies, energy dispersive X-ray spectroscopes, X-ray diffractions, X-ray elemental mapping, and line hardness measurements. The results revealed that friction welded Al-SS bimetallic pipes can sustain ultra-high vacuum pressure and cryogenic working environments without leak detection. Al-SS friction welded pipe resulted in high tensile strength with 72% of joint efficiency as compared to AA6063-T6 base material. Microstructure influences were observed largely in the AA6063-T6 side close to the Al-SS interface. The intermetallic compound of Fe3Al phase was identified with a reaction layer between Al-SS joints with varying thickness of 1.1 µm to 2.0 µm.