Principles and open questions in functional brain network reconstruction

Onerva Korhonen*, Massimiliano Zanin, David Papo

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

29 Downloads (Pure)


Graph theory is now becoming a standard tool in system-level neuroscience. However, endowing observed brain anatomy and dynamics with a complex network representation involves often covert theoretical assumptions and methodological choices which affect the way networks are reconstructed from experimental data, and ultimately the resulting network properties and their interpretation. Here, we review some fundamental conceptual underpinnings and technical issues associated with brain network reconstruction, and discuss how their mutual influence concurs in clarifying the organization of brain function.

Original languageEnglish
Number of pages31
JournalHuman Brain Mapping
Publication statusE-pub ahead of print - 20 May 2021
MoE publication typeA2 Review article in a scientific journal


  • brain dynamics
  • brain topology
  • edges
  • functional imaging
  • functional networks
  • nodes
  • resting state
  • structure–function relationship
  • temporal networks


Dive into the research topics of 'Principles and open questions in functional brain network reconstruction'. Together they form a unique fingerprint.

Cite this