Preparation of hierarchical superhydrophobic melamine-formaldehyde/Ag nanocomposite arrays as surface-enhanced Raman scattering substrates for ultrasensitive and reproducible detection of biomolecules

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@article{04d2c251bebd49c0ac6bf56f41315518,
title = "Preparation of hierarchical superhydrophobic melamine-formaldehyde/Ag nanocomposite arrays as surface-enhanced Raman scattering substrates for ultrasensitive and reproducible detection of biomolecules",
abstract = "Surface-enhanced Raman scattering (SERS) allows for label-free detection of analyte molecules with high sensitivity, but it is still vastly challenged for the detection of ultra-highly diluted analyte solutions in practice, e.g., femtomolar concentrates, 10 −15 M. Here, we report a facile approach for the fabrication of hierarchical superhydrophobic melamine-formaldehyde/Ag (MF/Ag) nanocomposite array substrates, applicable for ultra-highly sensitive SERS detection of biological analytes at very low concentrations up to femtomolar levels. Hierarchical superhydrophobic MF/Ag nanocomposite arrays are synthesized by integrating colloidal lithography at the air-liquid interface and in-situ interfacial reactions. These substrates can confine analyte molecules within the localized sensing regions, so as to effectively prevent the random spread of analyte molecules. In this way, these substrates are able to detect dopamine with a detection limit of 10 -15 M, and with a SERS enhancement factor (EF) as high as 3.21 × 10 10 . The substrates are durable and the SERS results are reproducible. For practical demonstration, these superhydrophobic SERS-active substrates are also applied for detecting proteins, lysozyme and hemoglobin at low concentrates. This work presents a straightforward way to synthesize the hierarchical superhydrophobic SERS-active substrates with superior sensitivity and long-term reproducibility, with rational modification, which might merit the practical SERS applications in detection of drug and pollutants in extremely dilute environments.",
keywords = "Ag nanoparticles, Hierarchical surface, Melamine-formaldehyde, Superhydrophobicity, Surface-enhanced Raman scattering",
author = "Ziwei Deng and Peihua Wen and Ni Wang and Bo Peng",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.snb.2019.02.068",
language = "English",
volume = "288",
pages = "20--26",
journal = "Sensors and Actuators B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",

}

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TY - JOUR

T1 - Preparation of hierarchical superhydrophobic melamine-formaldehyde/Ag nanocomposite arrays as surface-enhanced Raman scattering substrates for ultrasensitive and reproducible detection of biomolecules

AU - Deng, Ziwei

AU - Wen, Peihua

AU - Wang, Ni

AU - Peng, Bo

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Surface-enhanced Raman scattering (SERS) allows for label-free detection of analyte molecules with high sensitivity, but it is still vastly challenged for the detection of ultra-highly diluted analyte solutions in practice, e.g., femtomolar concentrates, 10 −15 M. Here, we report a facile approach for the fabrication of hierarchical superhydrophobic melamine-formaldehyde/Ag (MF/Ag) nanocomposite array substrates, applicable for ultra-highly sensitive SERS detection of biological analytes at very low concentrations up to femtomolar levels. Hierarchical superhydrophobic MF/Ag nanocomposite arrays are synthesized by integrating colloidal lithography at the air-liquid interface and in-situ interfacial reactions. These substrates can confine analyte molecules within the localized sensing regions, so as to effectively prevent the random spread of analyte molecules. In this way, these substrates are able to detect dopamine with a detection limit of 10 -15 M, and with a SERS enhancement factor (EF) as high as 3.21 × 10 10 . The substrates are durable and the SERS results are reproducible. For practical demonstration, these superhydrophobic SERS-active substrates are also applied for detecting proteins, lysozyme and hemoglobin at low concentrates. This work presents a straightforward way to synthesize the hierarchical superhydrophobic SERS-active substrates with superior sensitivity and long-term reproducibility, with rational modification, which might merit the practical SERS applications in detection of drug and pollutants in extremely dilute environments.

AB - Surface-enhanced Raman scattering (SERS) allows for label-free detection of analyte molecules with high sensitivity, but it is still vastly challenged for the detection of ultra-highly diluted analyte solutions in practice, e.g., femtomolar concentrates, 10 −15 M. Here, we report a facile approach for the fabrication of hierarchical superhydrophobic melamine-formaldehyde/Ag (MF/Ag) nanocomposite array substrates, applicable for ultra-highly sensitive SERS detection of biological analytes at very low concentrations up to femtomolar levels. Hierarchical superhydrophobic MF/Ag nanocomposite arrays are synthesized by integrating colloidal lithography at the air-liquid interface and in-situ interfacial reactions. These substrates can confine analyte molecules within the localized sensing regions, so as to effectively prevent the random spread of analyte molecules. In this way, these substrates are able to detect dopamine with a detection limit of 10 -15 M, and with a SERS enhancement factor (EF) as high as 3.21 × 10 10 . The substrates are durable and the SERS results are reproducible. For practical demonstration, these superhydrophobic SERS-active substrates are also applied for detecting proteins, lysozyme and hemoglobin at low concentrates. This work presents a straightforward way to synthesize the hierarchical superhydrophobic SERS-active substrates with superior sensitivity and long-term reproducibility, with rational modification, which might merit the practical SERS applications in detection of drug and pollutants in extremely dilute environments.

KW - Ag nanoparticles

KW - Hierarchical surface

KW - Melamine-formaldehyde

KW - Superhydrophobicity

KW - Surface-enhanced Raman scattering

UR - http://www.scopus.com/inward/record.url?scp=85062021590&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2019.02.068

DO - 10.1016/j.snb.2019.02.068

M3 - Article

VL - 288

SP - 20

EP - 26

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

SN - 0925-4005

ER -

ID: 32385455