Preparation of colloidal polydopamine/Au hollow spheres for enhanced ultrasound contrast imaging and photothermal therapy

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Preparation of colloidal polydopamine/Au hollow spheres for enhanced ultrasound contrast imaging and photothermal therapy. / Shang, Bin; Zhang, Xiaofen; Ji, Ri; Wang, Yanbing; Hu, He; Peng, Bo; Deng, Ziwei.

In: Materials Science and Engineering C, Vol. 106, 110174, 01.01.2020.

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@article{162830e2cd06457ba80627c8f49ecbda,
title = "Preparation of colloidal polydopamine/Au hollow spheres for enhanced ultrasound contrast imaging and photothermal therapy",
abstract = "Development of functional theranostic platform for systemic contrast-enhanced diagnostic imaging and therapy is of great necessity in nanomedicine. However, synthesizing the biocompatible theranostic agents with enhanced merits in imaging and therapy via a facile and green way is still highly challenged. Here, we report a novel theranostic agent based on colloidal polydopamine/Au (PDA/Au) hollow spheres, which are synthesized with combined use of PDA chemistry and sacrificial template techniques. Colloidal polystyrene (PS) spheres serve as the templates with coatings of a PDA shell and Au nanoparticles in sequence, which are subsequently removed with trichloromethane, giving rise to colloidal PDA/Au hollow spheres. Colloidal PDA/Au hollow spheres exhibit excellent contrast enhancement for ultrasound imaging, and can serve as the near-infrared (NIR) photoabsorbers for the effective photothermal ablation of 4 T1 breast cancer cells in vitro with minor cytotoxicity to living cells. This method suggests a novel avenue for theranostic treatment in oncology.",
keywords = "Au nanoparticles, Hollow spheres, Photothermal therapy, Polydopamine, Ultrasound imaging",
author = "Bin Shang and Xiaofen Zhang and Ri Ji and Yanbing Wang and He Hu and Bo Peng and Ziwei Deng",
year = "2020",
month = "1",
day = "1",
doi = "10.1016/j.msec.2019.110174",
language = "English",
volume = "106",
journal = "MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS",
issn = "0928-4931",
publisher = "Elsevier Science B.V.",

}

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TY - JOUR

T1 - Preparation of colloidal polydopamine/Au hollow spheres for enhanced ultrasound contrast imaging and photothermal therapy

AU - Shang, Bin

AU - Zhang, Xiaofen

AU - Ji, Ri

AU - Wang, Yanbing

AU - Hu, He

AU - Peng, Bo

AU - Deng, Ziwei

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Development of functional theranostic platform for systemic contrast-enhanced diagnostic imaging and therapy is of great necessity in nanomedicine. However, synthesizing the biocompatible theranostic agents with enhanced merits in imaging and therapy via a facile and green way is still highly challenged. Here, we report a novel theranostic agent based on colloidal polydopamine/Au (PDA/Au) hollow spheres, which are synthesized with combined use of PDA chemistry and sacrificial template techniques. Colloidal polystyrene (PS) spheres serve as the templates with coatings of a PDA shell and Au nanoparticles in sequence, which are subsequently removed with trichloromethane, giving rise to colloidal PDA/Au hollow spheres. Colloidal PDA/Au hollow spheres exhibit excellent contrast enhancement for ultrasound imaging, and can serve as the near-infrared (NIR) photoabsorbers for the effective photothermal ablation of 4 T1 breast cancer cells in vitro with minor cytotoxicity to living cells. This method suggests a novel avenue for theranostic treatment in oncology.

AB - Development of functional theranostic platform for systemic contrast-enhanced diagnostic imaging and therapy is of great necessity in nanomedicine. However, synthesizing the biocompatible theranostic agents with enhanced merits in imaging and therapy via a facile and green way is still highly challenged. Here, we report a novel theranostic agent based on colloidal polydopamine/Au (PDA/Au) hollow spheres, which are synthesized with combined use of PDA chemistry and sacrificial template techniques. Colloidal polystyrene (PS) spheres serve as the templates with coatings of a PDA shell and Au nanoparticles in sequence, which are subsequently removed with trichloromethane, giving rise to colloidal PDA/Au hollow spheres. Colloidal PDA/Au hollow spheres exhibit excellent contrast enhancement for ultrasound imaging, and can serve as the near-infrared (NIR) photoabsorbers for the effective photothermal ablation of 4 T1 breast cancer cells in vitro with minor cytotoxicity to living cells. This method suggests a novel avenue for theranostic treatment in oncology.

KW - Au nanoparticles

KW - Hollow spheres

KW - Photothermal therapy

KW - Polydopamine

KW - Ultrasound imaging

UR - http://www.scopus.com/inward/record.url?scp=85072039657&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2019.110174

DO - 10.1016/j.msec.2019.110174

M3 - Article

VL - 106

JO - MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS

JF - MATERIALS SCIENCE AND ENGINEERING C: MATERIALS FOR BIOLOGICAL APPLICATIONS

SN - 0928-4931

M1 - 110174

ER -

ID: 37042247