Abstract
Development of functional theranostic platform for systemic contrast-enhanced diagnostic imaging and therapy is of great necessity in nanomedicine. However, synthesizing the biocompatible theranostic agents with enhanced merits in imaging and therapy via a facile and green way is still highly challenged. Here, we report a novel theranostic agent based on colloidal polydopamine/Au (PDA/Au) hollow spheres, which are synthesized with combined use of PDA chemistry and sacrificial template techniques. Colloidal polystyrene (PS) spheres serve as the templates with coatings of a PDA shell and Au nanoparticles in sequence, which are subsequently removed with trichloromethane, giving rise to colloidal PDA/Au hollow spheres. Colloidal PDA/Au hollow spheres exhibit excellent contrast enhancement for ultrasound imaging, and can serve as the near-infrared (NIR) photoabsorbers for the effective photothermal ablation of 4 T1 breast cancer cells in vitro with minor cytotoxicity to living cells. This method suggests a novel avenue for theranostic treatment in oncology.
| Original language | English |
|---|---|
| Article number | 110174 |
| Journal | Materials Science and Engineering C |
| Volume | 106 |
| DOIs | |
| Publication status | Published - 1 Jan 2020 |
| MoE publication type | A1 Journal article-refereed |
Funding
We acknowledge the National Natural Science Foundation of China (No. 51473089 ), the Natural Science Basic Research Plan in Shaanxi Province of China (No. 2018JM5093 ), the Program for Science & Technology Innovation Team of Shaanxi Province (No. 2018TD-030 ), the Science and Technology Program of Shaanxi Province (No. 2015KJXX-20 ) and the Fundamental Research Funds for the Central Universities (No. GK201702009 , GK201901002 ) for financial supports. B.P. thanks the support from the Academy of Finland (No. 321443 and No. 328942 ). Appendix A
Keywords
- Au nanoparticles
- Hollow spheres
- Photothermal therapy
- Polydopamine
- Ultrasound imaging
