Preparation of 5-substituted 2-carboxyindoles on solid support

Jan Tois; Robert Franzén; Olli Aitio; Katri Huikko; Jyrki Taskinen

doi:10.1016/S0040-4039(00)00151-9

Preparation of 5-substituted 2-carboxyindoles on solid support

Jan Tois
, Robert Franzén^*
, Olli Aitio
, Katri Huikko
, Jyrki Taskinen

^*Corresponding author for this work

Not published at Aalto University

University of Helsinki

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

Abstract

The preparation of 5-substituted 2-carboxyindoles on solid support is reported. In the approach, the indole moiety is synthesized in solution phase, followed by nitro-group reduction, reductive amination and alkylation on solid support. The method provides a simple and convenient route for the preparation of 5-substituted 2-carboxyindoles with high purity and good yield. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2443-2446
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	14
DOIs	https://doi.org/10.1016/S0040-4039(00)00151-9
Publication status	Published - 1 Apr 2000
MoE publication type	A1 Journal article-refereed

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title = "Preparation of 5-substituted 2-carboxyindoles on solid support",

abstract = "The preparation of 5-substituted 2-carboxyindoles on solid support is reported. In the approach, the indole moiety is synthesized in solution phase, followed by nitro-group reduction, reductive amination and alkylation on solid support. The method provides a simple and convenient route for the preparation of 5-substituted 2-carboxyindoles with high purity and good yield. (C) 2000 Elsevier Science Ltd.",

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T1 - Preparation of 5-substituted 2-carboxyindoles on solid support

AU - Tois, Jan

AU - Franzén, Robert

AU - Aitio, Olli

AU - Huikko, Katri

AU - Taskinen, Jyrki

PY - 2000/4/1

Y1 - 2000/4/1

N2 - The preparation of 5-substituted 2-carboxyindoles on solid support is reported. In the approach, the indole moiety is synthesized in solution phase, followed by nitro-group reduction, reductive amination and alkylation on solid support. The method provides a simple and convenient route for the preparation of 5-substituted 2-carboxyindoles with high purity and good yield. (C) 2000 Elsevier Science Ltd.

AB - The preparation of 5-substituted 2-carboxyindoles on solid support is reported. In the approach, the indole moiety is synthesized in solution phase, followed by nitro-group reduction, reductive amination and alkylation on solid support. The method provides a simple and convenient route for the preparation of 5-substituted 2-carboxyindoles with high purity and good yield. (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034175579

U2 - 10.1016/S0040-4039(00)00151-9

DO - 10.1016/S0040-4039(00)00151-9

M3 - Article

AN - SCOPUS:0034175579

SN - 0040-4039

VL - 41

SP - 2443

EP - 2446

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 14

ER -

Preparation of 5-substituted 2-carboxyindoles on solid support

Abstract

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