Pre-treated bioactive composite in rat soft tissue

T. Tirri*, T. Jaakkola, T. Närhi, J. Rich, J. Seppälä, A. Yli-Urpo

*Corresponding author for this work

    Research output: Contribution to journalArticleScientificpeer-review


    Effect of in vitro formed calcium phosphate surface on a bioactive composite was studied in rat subcutaneous tissue. Pre-treatment in simulated body fluid (SBF) for 14 days resulted in the formation of calcium phosphate deposites on the composite surface whereas no formation was observed on the copolymer without bioactive glass. Pre-treatment had no effect on short term soft tissue reactions around the copolymer without bioactive glass granules whereas the calcium phosphate surface formed on the composite resulted in delayed healing of the surgical wound. This may be due to mechanical stress caused by rough calcium phosphate surface.

    Original languageEnglish
    Pages (from-to)653-656
    Number of pages4
    JournalKey Engineering Materials
    Publication statusPublished - 2001
    MoE publication typeA1 Journal article-refereed


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