Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

Alexandra Zhernakova*, Alexander Kurilshikov, Marc Jan Bonder, Ettje F. Tigchelaar, Melanie Schirmer, Tommi Vatanen, Zlatan Mujagic, Arnau Vich Vila, Gwen Falony, Sara Vieira-Silva, Jun Wang, Floris Imhann, Eelke Brandsma, Soesma A. Jankipersadsing, Marie Joossens, Maria Carmen Cenit, Patrick Deelen, Morris A. Swertz, Rinse K. Weersma, Edith J M FeskensMihai G. Netea, Dirk Gevers, Daisy Jonkers, Lude Franke, Yurii S. Aulchenko, Curtis Huttenhower, Jeroen Raes, Marten H. Hofker, Ramnik J. Xavier, Cisca Wijmenga, Jingyuan Fu

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

676 Citations (Scopus)

Abstract

Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition.We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalScience
Volume352
Issue number6285
DOIs
Publication statusPublished - 29 Apr 2016
MoE publication typeA1 Journal article-refereed

Keywords

  • CHROMOGRANIN-A
  • ENTEROTYPES
  • POLYPHENOLS
  • METABOLISM
  • CHILDREN

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