Poor glycemic control as a risk factor for pseudophakic cystoid macular edema in patients with diabetes

Petteri Ylinen, Ilkka Laine, Juha Matti Lindholm, Raimo Tuuminen*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)

Abstract

Purpose To specify the risk factors for pseudophakic cystoid macular edema (CME) in patients with diabetes. Setting Kymenlaakso Central Hospital, Unit of Ophthalmology, Kotka, Finland. Design Prospective case series. Methods Patients with type 1 or type 2 diabetes having routine cataract surgery were evaluated. Spectral-domain optical coherence tomography imaging was performed before surgery and 1 month postoperatively. Results The study comprised 93 patients (95 eyes). The central retinal thickness increase was 9.7 μm ± 1.7 (SEM) in diabetic patients with no retinopathy, 22.7 ± 8.6 μm in those who had nonproliferative retinopathy, and 73.8 ± 37.4 μm in those who had proliferative retinopathy (P <.001). The central retinal thickness increase was greater in the eyes of diabetic patients with insulin dependence than in eyes of patients using noninsulin medication (21.9 ± 5.9 μm versus 8.3 ± 1.8 μm, P =.017). Serum hemoglobin A1c concentration and inversely, patient age, were associated with central retinal thickness increase, even after adjustment for confounding factors (r = 0.607, P <.001 and r = 0.417, P =.001, respectively). The central retinal thickness change was smaller in the eyes of patients who had a nonsteroidal antiinflammatory drug (NSAID) as their postoperative antiinflammatory medication than in eyes of patients who were not prescribed NSAID medication when retinopathy was analyzed as a covariant (8.2 ± 3.6 μm versus 13.6 ± 2.9 μm, P =.016). Conclusions Young patient age and poor glycemic control were risk factors for postoperative central retinal thickness increase. This study showed it is necessary to identify, effectively treat, and follow-up with patients with diabetes who are at a greater risk for pseudophakic CME.

Original languageEnglish
Pages (from-to)1376-1382
Number of pages7
JournalJournal of Cataract and Refractive Surgery
Volume43
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017
MoE publication typeA1 Journal article-refereed

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