Polysulfobetaine-surfactant solutions and their use in stabilizing hydrophobic compounds in saline solution

Jukka Niskanen; Jaana Vapaavuori; Christian Pellerin; Francoise M. Winnik; Heikki Tenhu

doi:10.1016/j.polymer.2017.08.057

Polysulfobetaine-surfactant solutions and their use in stabilizing hydrophobic compounds in saline solution

Jukka Niskanen, Jaana Vapaavuori, Christian Pellerin, Francoise M. Winnik, Heikki Tenhu^*

^*Corresponding author for this work

Not published at Aalto University

Research output: Contribution to journal › Article › Scientific › peer-review

17 Citations (Scopus)

Abstract

A star shaped poly(sulfobetaine methacrylate) (PSBMA) and its linear analogs, display upper-critical solution-temperature (UCST) type behavior in 0.1 M NaCI. The presence of sodium dodecyl sulfate (SDS) or cetyl trimethyl ammonium bromide (CTAB) has a significant effect on the thermal transition of the polymer. The association of the polymer with the surfactants is confirmed by isothermal titration calorimetry (ITC) and infrared (IR) spectroscopy. SDS forms hydrophobic domains along the polymer chains, preventing the polymers from undergoing a thermal phase transition. These domains can be used to capture 1-anilino-8-naphthalenesulfonate (1,8-ANS), pyrene and curcumin, and increase their fluorescence intensity. Curcumin, which is unstable in aqueous solutions, is stabilized against degradation upon solubilization by the PSBMA-SDS complexes. (C) 2017 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	77-87
Number of pages	11
Journal	Polymer
Volume	127
DOIs	https://doi.org/10.1016/j.polymer.2017.08.057
Publication status	Published - 3 Oct 2017
MoE publication type	A1 Journal article-refereed

Keywords

ISOTHERMAL TITRATION CALORIMETRY
CONTROL ESIPT PROCESS
BETA-CYCLODEXTRIN
AQUEOUS-SOLUTION
PHASE-TRANSITION
IN-VIVO
STAR
CURCUMIN
POLYMERS
DELIVERY

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@article{e4ca67aa5ec243c3ae016059182baff3,

title = "Polysulfobetaine-surfactant solutions and their use in stabilizing hydrophobic compounds in saline solution",

abstract = "A star shaped poly(sulfobetaine methacrylate) (PSBMA) and its linear analogs, display upper-critical solution-temperature (UCST) type behavior in 0.1 M NaCI. The presence of sodium dodecyl sulfate (SDS) or cetyl trimethyl ammonium bromide (CTAB) has a significant effect on the thermal transition of the polymer. The association of the polymer with the surfactants is confirmed by isothermal titration calorimetry (ITC) and infrared (IR) spectroscopy. SDS forms hydrophobic domains along the polymer chains, preventing the polymers from undergoing a thermal phase transition. These domains can be used to capture 1-anilino-8-naphthalenesulfonate (1,8-ANS), pyrene and curcumin, and increase their fluorescence intensity. Curcumin, which is unstable in aqueous solutions, is stabilized against degradation upon solubilization by the PSBMA-SDS complexes. (C) 2017 Elsevier Ltd. All rights reserved.",

keywords = "ISOTHERMAL TITRATION CALORIMETRY, CONTROL ESIPT PROCESS, BETA-CYCLODEXTRIN, AQUEOUS-SOLUTION, PHASE-TRANSITION, IN-VIVO, STAR, CURCUMIN, POLYMERS, DELIVERY",

author = "Jukka Niskanen and Jaana Vapaavuori and Christian Pellerin and Winnik, {Francoise M.} and Heikki Tenhu",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = oct,

day = "3",

doi = "10.1016/j.polymer.2017.08.057",

language = "English",

volume = "127",

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T1 - Polysulfobetaine-surfactant solutions and their use in stabilizing hydrophobic compounds in saline solution

AU - Niskanen, Jukka

AU - Vapaavuori, Jaana

AU - Pellerin, Christian

AU - Winnik, Francoise M.

AU - Tenhu, Heikki

PY - 2017/10/3

Y1 - 2017/10/3

N2 - A star shaped poly(sulfobetaine methacrylate) (PSBMA) and its linear analogs, display upper-critical solution-temperature (UCST) type behavior in 0.1 M NaCI. The presence of sodium dodecyl sulfate (SDS) or cetyl trimethyl ammonium bromide (CTAB) has a significant effect on the thermal transition of the polymer. The association of the polymer with the surfactants is confirmed by isothermal titration calorimetry (ITC) and infrared (IR) spectroscopy. SDS forms hydrophobic domains along the polymer chains, preventing the polymers from undergoing a thermal phase transition. These domains can be used to capture 1-anilino-8-naphthalenesulfonate (1,8-ANS), pyrene and curcumin, and increase their fluorescence intensity. Curcumin, which is unstable in aqueous solutions, is stabilized against degradation upon solubilization by the PSBMA-SDS complexes. (C) 2017 Elsevier Ltd. All rights reserved.

AB - A star shaped poly(sulfobetaine methacrylate) (PSBMA) and its linear analogs, display upper-critical solution-temperature (UCST) type behavior in 0.1 M NaCI. The presence of sodium dodecyl sulfate (SDS) or cetyl trimethyl ammonium bromide (CTAB) has a significant effect on the thermal transition of the polymer. The association of the polymer with the surfactants is confirmed by isothermal titration calorimetry (ITC) and infrared (IR) spectroscopy. SDS forms hydrophobic domains along the polymer chains, preventing the polymers from undergoing a thermal phase transition. These domains can be used to capture 1-anilino-8-naphthalenesulfonate (1,8-ANS), pyrene and curcumin, and increase their fluorescence intensity. Curcumin, which is unstable in aqueous solutions, is stabilized against degradation upon solubilization by the PSBMA-SDS complexes. (C) 2017 Elsevier Ltd. All rights reserved.

KW - ISOTHERMAL TITRATION CALORIMETRY

KW - CONTROL ESIPT PROCESS

KW - BETA-CYCLODEXTRIN

KW - AQUEOUS-SOLUTION

KW - PHASE-TRANSITION

KW - IN-VIVO

KW - STAR

KW - CURCUMIN

KW - POLYMERS

KW - DELIVERY

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U2 - 10.1016/j.polymer.2017.08.057

DO - 10.1016/j.polymer.2017.08.057

M3 - Article

SN - 0032-3861

VL - 127

SP - 77

EP - 87

JO - Polymer

JF - Polymer

ER -

Polysulfobetaine-surfactant solutions and their use in stabilizing hydrophobic compounds in saline solution

Abstract

Keywords

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