Polymer translocation through a nanopore assisted by an environment of active rods

Hamidreza Khalilian*, Jalal Sarabadani, Tapio Ala-Nissila

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

We use a combination of computer simulations and isoflux tension propagation (IFTP) theory to investigate the translocation dynamics of a flexible linear polymer through a nanopore into an environment composed of repulsive active rods in two dimensions. We demonstrate that the rod activity induces a crowding effect on the polymer, leading to a time-dependent effective net force that facilitates translocation into the active environment. Incorporating this force into the IFTP theory for pore-driven translocation allows us to characterize translocation dynamics in detail and derive a scaling form for the average translocation time as τ ∼ N1+v01 Lvt/FSP, where N01, Lr, and FSP are the initial contour length of the cis-side subchain, rod length, and self-propelling force acting on the rods, respectively, and ν is the equilibrium Flory scaling exponent.

Original languageEnglish
Article number013080
Number of pages7
JournalPHYSICAL REVIEW RESEARCH
Volume3
Issue number1
DOIs
Publication statusPublished - 26 Jan 2021
MoE publication typeA1 Journal article-refereed

Keywords

  • DNA
  • FORCE
  • TRANSITION
  • ROTATION
  • SWIMMER
  • MOTION

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