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Abstract
We consider the dynamics of a translocation process of a flexible linear polymer through a nanopore into an environment of active rods in the trans side. Using Langevin dynamics simulations, we show that the rods facilitate translocation to the trans side even when there are initially more monomers on the cis than on the trans side. Structural analysis of the translocating polymer reveals that active rods induce a folded structure to the trans-side subchain in the case of successful translocation events. By keeping the initial number of monomers on the cis-side subchain fixed, we map out a state diagram for successful events as a function of the rod number density for a variety of system parameters. This reveals competition between facilitation by the rods at low densities and crowding that hinders translocation at higher densities.
| Original language | English |
|---|---|
| Article number | 023107 |
| Journal | Physical Review Research |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2023 |
| MoE publication type | A1 Journal article-refereed |
Funding
Computational resources from CSC - Center for Scientific Computing Ltd. and from the Aalto University School of Science “Science-IT” project are gratefully acknowledged. T.A-N. has been supported in part by the Academy of Finland through its PolyDyna (No. 307806) and QFT Center of Excellence Program Grants (No. 312298).
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PolyDyna: Coarse-Grained Modeling of Translocation and Polymer Dynamics in Nanofluidic Systems
Ala-Nissilä, T. (Principal investigator), Channe, S. (Project Member), Hashemi Petrudi, A. (Project Member), Conley, K. (Project Member), Muhli, H. (Project Member), Fan, Z. (Project Member), Seyedheydari, F. (Project Member), Alipour, S. (Project Member), Vadimov, V. (Project Member), Molla, J. (Project Member), Hirvonen, P. (Project Member), Alcanzare, M. (Project Member), Babu, A. (Project Member), Ferreira Sampaio, R. (Project Member) & Achim, C. (Project Member)
01/09/2017 → 31/12/2021
Project: Academy of Finland: Other research funding