Piperazine Bridged Resorcinarene Cages

Ngong Kodiah Beyeh, Arto Valkonen, Kari Rissanen

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)

Abstract

The one-pot Mannich condensation of resorcinarenes with piperazine and an excess of formaldehyde under high dilution conditions results in a helical cage, namely, a covalently linked dimer of two resorcinarenes connected via four piperazine bridges in yields ranging from 20 to 40%. The compounds were analyzed by NMR spectroscopy, ESI mass spectrometry, and single crystal X-ray diffraction. The helical cages can encapsulate small guest molecules by adapting the cavity volume by changing the helical pitch according to the guest size.
Original languageEnglish
Pages (from-to)1392–1395
JournalORGANIC LETTERS
Volume12
Issue number7
DOIs
Publication statusPublished - Mar 2010
MoE publication typeA1 Journal article-refereed

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