Phytomedicines targeting cancer stem cells: Therapeutic opportunities and prospects for pharmaceutical development

Piyush Kumar Gupta*, Mrunmayee Saraff, Rekha Gahtori, Nidhi Negi, Surya Kant Tripathi, Jatin Kumar, Sanjay Kumar, Saad Hamad Aldhayan, Sugapriya Dhanasekaran, Mosleh Mohammad Abomughaid, Kamal Dua, Rohit Gundamaraju, Shreesh Ojha, Janne Ruokolainen, Niraj Kumar Jha, Kavindra Kumar Kesari

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

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Abstract

The presence of small subpopulations of cells within tumor cells are known as cancer stem cells (CSCs). These cells have been the reason for metastasis, resistance with chemotherapy or radiotherapy, and tumor relapse in several types of cancers. CSCs underwent to epithelial– mesenchymal transition (EMT) and resulted in the development of aggressive tumors. CSCs have potential to modulate numerous signaling pathways including Wnt, Hh, and Notch, therefore increasing the stem-like characteristics of cancer cells. The raised expression of drug efflux pump and suppression of apoptosis has shown increased resistance with anti-cancer drugs. Among many agents which were shown to modulate these, the plant-derived bioactive agents appear to modulate these key regulators and were shown to remove CSCs. This review aims to comprehensively scrutinize the preclinical and clinical studies demonstrating the effects of phytocompounds on CSCs isolated from various tumors. Based on the available convincing literature from preclinical studies, with some clinical data, it is apparent that selective targeting of CSCs with plants, plant preparations, and plant-derived bioactive compounds, termed phytochemicals, may be a promising strategy for the treatment of relapsed cancers.

Original languageEnglish
Article number676
Number of pages25
JournalPharmaceuticals
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2021
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Clinical research
  • Epithelial–mesenchymal transition
  • Phytochemicals
  • Phytomedicines
  • Preclinical
  • Signaling pathway
  • Stem cells

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