Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Diana Ciolacu*, Cyrielle Rudaz, Mihai Vasilescu, Tatiana Budtova

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

30 Citations (Scopus)

Abstract

Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

Original languageEnglish
Pages (from-to)392-400
Number of pages9
JournalCarbohydrate Polymers
Volume151
DOIs
Publication statusPublished - 20 Oct 2016
MoE publication typeA1 Journal article-refereed

Keywords

  • Cellulose
  • Controlled release
  • Cross-linking
  • Cryogel
  • Hydrogel
  • Swelling

Fingerprint Dive into the research topics of 'Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release'. Together they form a unique fingerprint.

Cite this