Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Diana Ciolacu; Cyrielle Rudaz; Mihai Vasilescu; Tatiana Budtova

doi:10.1016/j.carbpol.2016.05.084

Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Diana Ciolacu^*, Cyrielle Rudaz, Mihai Vasilescu, Tatiana Budtova

^*Corresponding author for this work

Not published at Aalto University

Research output: Contribution to journal › Article › Scientific › peer-review

96 Citations (Scopus)

Abstract

Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

Original language	English
Pages (from-to)	392-400
Number of pages	9
Journal	Carbohydrate Polymers
Volume	151
DOIs	https://doi.org/10.1016/j.carbpol.2016.05.084
Publication status	Published - 20 Oct 2016
MoE publication type	A1 Journal article-refereed

Keywords

Cellulose
Controlled release
Cross-linking
Cryogel
Hydrogel
Swelling

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10.1016/j.carbpol.2016.05.084

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title = "Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release",

abstract = "Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.",

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author = "Diana Ciolacu and Cyrielle Rudaz and Mihai Vasilescu and Tatiana Budtova",

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language = "English",

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TY - JOUR

T1 - Physically and chemically cross-linked cellulose cryogels

T2 - Structure, properties and application for controlled release

AU - Ciolacu, Diana

AU - Rudaz, Cyrielle

AU - Vasilescu, Mihai

AU - Budtova, Tatiana

PY - 2016/10/20

Y1 - 2016/10/20

N2 - Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

AB - Porous cellulose matrices were prepared via cellulose dissolution in 8 wt% NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

KW - Cellulose

KW - Controlled release

KW - Cross-linking

KW - Cryogel

KW - Hydrogel

KW - Swelling

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U2 - 10.1016/j.carbpol.2016.05.084

DO - 10.1016/j.carbpol.2016.05.084

M3 - Article

AN - SCOPUS:84975496318

SN - 0144-8617

VL - 151

SP - 392

EP - 400

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

ER -

Physically and chemically cross-linked cellulose cryogels: Structure, properties and application for controlled release

Abstract

Keywords

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