Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

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In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.

Original languageEnglish
Pages (from-to)7341-7344
Number of pages4
JournalChemical Communications
Issue number53
Early online date27 May 2020
Publication statusPublished - 7 Jul 2020
MoE publication typeA1 Journal article-refereed


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