Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

Ahmed Shaukat; Eduardo Anaya-Plaza; Sofia Julin; Veikko Linko; Tomas Torres; Andrés de la Escosura; Mauri A. Kostiainen

doi:10.1039/D0CC01916J

Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

Ahmed Shaukat, Eduardo Anaya-Plaza, Sofia Julin, Veikko Linko, Tomas Torres, Andrés de la Escosura, Mauri A. Kostiainen

Research output: Contribution to journal › Article › Scientific › peer-review

3 Citations (Scopus)

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Abstract

n this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.

Original language	English
Pages (from-to)	7341-7344
Journal	Chemical Communications
Volume	56
Issue number	53
DOIs	https://doi.org/10.1039/D0CC01916J
Publication status	Published - 27 May 2020
MoE publication type	A1 Journal article-refereed

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https://doi.org/10.1039/D0CC01916J

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1 Active
2 Finished

SYNVIRO: Synthetic Virology Toolbox for the Encapsulation of Therapeutic Polyelectrolytes (SYNVIRO)
Julin, S., Kostiainen, M., Liu, Q., Välimäki, S., Korpi, A., Ahmed, A. & Anaya Plaza, E.
01/09/2017 → 31/08/2021
Project: Academy of Finland: Other research funding
BiHyOMat: BioHybrid Optoelectronic Materials
Kostiainen, M. & Anaya Plaza, E.
01/06/2018 → 20/06/2020
Project: EU: Other research funding
Rationally designed molecular devices through nucleic acid nanotechnology
Linko, V.
01/09/2015 → 31/08/2018
Project: Academy of Finland: Other research funding

Bioeconomy Research Infrastructure
Jukka Seppälä (Manager)
School of Chemical Engineering
Facility/equipment: Facility
OtaNano - Nanomicroscopy Center
Janne Ruokolainen (Manager)
Department of Applied Physics
Facility/equipment: Facility

Cite this

@article{5b83600d7d14472585c5df253ff433cd,

title = "Phthalocyanine–DNA origami complexes with enhanced stability and optical properties",

abstract = "n this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.",

author = "Ahmed Shaukat and Eduardo Anaya-Plaza and Sofia Julin and Veikko Linko and Tomas Torres and Escosura, {Andr{\'e}s de la} and Kostiainen, {Mauri A.}",

note = "| openaire: EC/H2020/794536/EU//BiHyOMat",

year = "2020",

month = may,

day = "27",

doi = "10.1039/D0CC01916J",

language = "English",

volume = "56",

pages = "7341--7344",

journal = "Chemical Communications",

issn = "1359-7345",

number = "53",

}

Phthalocyanine–DNA origami complexes with enhanced stability and optical properties. / Shaukat, Ahmed; Anaya-Plaza, Eduardo ; Julin, Sofia ; Linko, Veikko; Torres, Tomas; Escosura, Andrés de la; Kostiainen, Mauri A.

In: Chemical Communications, Vol. 56, No. 53, 27.05.2020, p. 7341-7344.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

AU - Shaukat, Ahmed

AU - Anaya-Plaza, Eduardo

AU - Julin, Sofia

AU - Linko, Veikko

AU - Torres, Tomas

AU - Escosura, Andrés de la

AU - Kostiainen, Mauri A.

N1 - | openaire: EC/H2020/794536/EU//BiHyOMat

PY - 2020/5/27

Y1 - 2020/5/27

N2 - n this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.

AB - n this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically relevant media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA nanocarriers. The studied complexes may find use in technologies related to the photogeneration of singlet oxygen, e.g., photocatalysis, diagnositic arrays and photodynamic therapy.

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DO - 10.1039/D0CC01916J

M3 - Article

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VL - 56

SP - 7341

EP - 7344

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 53

ER -

Phthalocyanine–DNA origami complexes with enhanced stability and optical properties

Abstract

Access to Document

SYNVIRO: Synthetic Virology Toolbox for the Encapsulation of Therapeutic Polyelectrolytes (SYNVIRO)

BiHyOMat: BioHybrid Optoelectronic Materials

Rationally designed molecular devices through nucleic acid nanotechnology

Bioeconomy Research Infrastructure

OtaNano - Nanomicroscopy Center

Cite this