Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

Research output: Contribution to journalArticleScientificpeer-review


Research units

  • Ramon Llull University
  • Universidad Autónoma de Madrid
  • Ramón y Cajal University Hospital


The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.


Original languageEnglish
Pages (from-to)4320-4326
Number of pages7
Issue number18
Publication statusPublished - 28 Mar 2017
MoE publication typeA1 Journal article-refereed

    Research areas

  • cellulose nanocrystals, functional materials, photoantimicrobial biohybrids, phthalocyanine, supramolecular complex

ID: 11609145