Phase synchrony among neuronal oscillations in the human cortex

J. Matias Palva*, Satu Palva, Kai Kaila

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

427 Citations (Scopus)

Abstract

Synchronization of neuronal activity, often associated with network oscillations, is thought to provide a means for integrating anatomically distributed processing in the brain. Neuronal processing, however, involves simultaneous oscillations in various frequency bands. The mechanisms involved in the integration of such spectrally distributed processing have remained enigmatic. We demonstrate, using magnetoencephalography, that robust cross-frequency phase synchrony is present in the human cortex among oscillations with frequencies from 3 to 80 Hz. Continuous mental arithmetic tasks demanding the retention and summation of items in the working memory enhanced the cross-frequency phase synchrony among α (∼10 Hz), β (∼20 Hz), and γ (∼30-40 Hz) oscillations. These tasks also enhanced the "classical" within-frequency synchrony in these frequency bands, but the spatial patterns of α, β, and γ synchronies were distinct and, furthermore, separate from the patterns of cross-frequency phase synchrony. Interestingly, an increase in task load resulted in an enhancement of phase synchrony that was most prominent between γ- and α-band oscillations. These data indicate that cross-frequency phase synchrony is a salient characteristic of ongoing activity in the human cortex and that it is modulated by cognitive task demands. The enhancement of cross-frequency phase synchrony among functionally and spatially distinct networks during mental arithmetic tasks posits it as a candidate mechanism for the integration of spectrally distributed processing.

Original languageEnglish
Pages (from-to)3962-3972
Number of pages11
JournalJOURNAL OF NEUROSCIENCE
Volume25
Issue number15
DOIs
Publication statusPublished - 13 Apr 2005
MoE publication typeA1 Journal article-refereed

Keywords

  • α
  • γ
  • Attention
  • Cortex
  • Oscillator
  • Parietal
  • Synchrony
  • Working memory

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