Phase-Based Cortical Synchrony Is Affected by Prematurity

Pauliina Yrjola, Susanna Stjerna, J. Matias Palva, Sampsa Vanhatalo, Anton Tokariev

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)
10 Downloads (Pure)

Abstract

Inter-areal synchronization by phase-phase correlations (PPCs) of cortical oscillations mediates many higher neurocognitive functions, which are often affected by prematurity, a globally prominent neurodevelopmental risk factor. Here, we used electroencephalography to examine brain-wide cortical PPC networks at term-equivalent age, comparing human infants after early prematurity to a cohort of healthy controls. We found that prematurity affected these networks in a sleep state-specific manner, and the differences between groups were also frequency-selective, involving brain-wide connections. The strength of synchronization in these networks was predictive of clinical outcomes in the preterm infants. These findings show that prematurity affects PPC networks in a clinically significant manner, suggesting early functional biomarkers of later neurodevelopmental compromise that may be used in clinical or translational studies after early neonatal adversity.

Original languageEnglish
Pages (from-to)2265-2276
Number of pages12
JournalCerebral Cortex
Volume32
Issue number10
DOIs
Publication statusPublished - 14 May 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • brain networks
  • neonatal EEG
  • neurodevelopment
  • phase coupling
  • preterm infant
  • NEONATAL EEG
  • FUNCTIONAL CONNECTIVITY
  • PRETERM INFANTS
  • BRAIN NETWORKS
  • TERM
  • MEG
  • PATHWAYS
  • INDEX
  • AGE

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