Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter

Aino E. Laine; Christopher Lood; Ari M.P. Koskinen

doi:10.3390/molecules19021544

Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter

Aino E. Laine, Christopher Lood, Ari M.P. Koskinen

Research output: Contribution to journal › Review Article › Scientific › peer-review

62 Citations (Scopus)

107 Downloads (Pure)

Abstract

1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important
group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been the target of extensive synthetic efforts due to the presence of the scaffold in numerous natural products and synthetic targets. This review briefly summarizes the methods to obtain the C1 stereocenter and concentrates on evaluating the pharmacological importance of optically active C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral and antitumor activities.

Original language	English
Pages (from-to)	1544-1567
Journal	MOLECULES
Volume	19
Issue number	2
DOIs	https://doi.org/10.3390/molecules19021544
Publication status	Published - 2014
MoE publication type	A2 Review article in a scientific journal

Keywords

tetrahydro-beta-carboline
TH-beta-C
pharmacological importance
biological activity
C1-substituted TH-beta-C

Access to Document

10.3390/molecules19021544

molecules-19-01544Final published version, 886 KB

http://www.mdpi.com/1420-3049/19/2/1544/htm

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Laine, A. E., Lood, C., & Koskinen, A. M. P. (2014). Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter. MOLECULES, 19(2), 1544-1567. https://doi.org/10.3390/molecules19021544

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