Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter

Aino E. Laine, Christopher Lood, Ari M.P. Koskinen

    Research output: Contribution to journalReview ArticleScientificpeer-review

    62 Citations (Scopus)
    107 Downloads (Pure)

    Abstract

    1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important
    group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been the target of extensive synthetic efforts due to the presence of the scaffold in numerous natural products and synthetic targets. This review briefly summarizes the methods to obtain the C1 stereocenter and concentrates on evaluating the pharmacological importance of optically active C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral and antitumor activities.
    Original languageEnglish
    Pages (from-to)1544-1567
    JournalMOLECULES
    Volume19
    Issue number2
    DOIs
    Publication statusPublished - 2014
    MoE publication typeA2 Review article in a scientific journal

    Keywords

    • tetrahydro-beta-carboline
    • TH-beta-C
    • pharmacological importance
    • biological activity
    • C1-substituted TH-beta-C

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