Abstract
1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important
group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been the target of extensive synthetic efforts due to the presence of the scaffold in numerous natural products and synthetic targets. This review briefly summarizes the methods to obtain the C1 stereocenter and concentrates on evaluating the pharmacological importance of optically active C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral and antitumor activities.
group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been the target of extensive synthetic efforts due to the presence of the scaffold in numerous natural products and synthetic targets. This review briefly summarizes the methods to obtain the C1 stereocenter and concentrates on evaluating the pharmacological importance of optically active C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral and antitumor activities.
Original language | English |
---|---|
Pages (from-to) | 1544-1567 |
Journal | MOLECULES |
Volume | 19 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2014 |
MoE publication type | A2 Review article in a scientific journal |
Keywords
- tetrahydro-beta-carboline
- TH-beta-C
- pharmacological importance
- biological activity
- C1-substituted TH-beta-C
Fingerprint
Dive into the research topics of 'Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter'. Together they form a unique fingerprint.Equipment
-
Bioeconomy Research Infrastructure
Jukka Seppälä (Manager)
School of Chemical TechnologyFacility/equipment: Facility