Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides

Valeria Castelletto; Jani Seitsonen; Janne Ruokolainen; Cristian Piras; Rainer Cramer; Charlotte J.C. Edwards-Gayle; Ian W. Hamley

doi:10.1039/d0cc04299d

Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides

Valeria Castelletto, Jani Seitsonen, Janne Ruokolainen, Cristian Piras, Rainer Cramer, Charlotte J.C. Edwards-Gayle, Ian W. Hamley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

75 Downloads (Pure)

Abstract

The designed arginine-rich surfactant-like peptide R₃L₁₂(arginine₃-leucine₁₂) is shown to form a remarkable diversity of self-assembled nanostructures in aqueous solution, depending on pH, including nanotubes, mesh-like tubular networks in three-dimensions and square planar arrays in two-dimensions. These structures are built from α-helical antiparallel coiled-coil peptide dimers arranged perpendicular to the nanotube axis, in a “cross-α” nanotube structure. The aggregation behavior is rationalized based on the effects of dimensionality, and the balance of hydrophobic and electrostatic interactions. The nanotube and nanomesh structures display arginine at high density on their surfaces, which may be valuable for future applications.

Original language	English
Pages (from-to)	11977-11980
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	80
DOIs	https://doi.org/10.1039/d0cc04299d
Publication status	Published - 14 Oct 2020
MoE publication type	A1 Journal article-refereed

Access to Document

10.1039/d0cc04299d

Castelletto_Peptide_Nanotubes.d0cc04299d-2Final published version, 2.67 MBLicence: CC BY-NC

Cite this

@article{ec22c50551274630b7df8c13f306cbd5,

title = "Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides",

abstract = "The designed arginine-rich surfactant-like peptide R3L12(arginine3-leucine12) is shown to form a remarkable diversity of self-assembled nanostructures in aqueous solution, depending on pH, including nanotubes, mesh-like tubular networks in three-dimensions and square planar arrays in two-dimensions. These structures are built from α-helical antiparallel coiled-coil peptide dimers arranged perpendicular to the nanotube axis, in a “cross-α” nanotube structure. The aggregation behavior is rationalized based on the effects of dimensionality, and the balance of hydrophobic and electrostatic interactions. The nanotube and nanomesh structures display arginine at high density on their surfaces, which may be valuable for future applications.",

author = "Valeria Castelletto and Jani Seitsonen and Janne Ruokolainen and Cristian Piras and Rainer Cramer and Edwards-Gayle, {Charlotte J.C.} and Hamley, {Ian W.}",

year = "2020",

month = oct,

day = "14",

doi = "10.1039/d0cc04299d",

language = "English",

volume = "56",

pages = "11977--11980",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "80",

}

TY - JOUR

T1 - Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides

AU - Castelletto, Valeria

AU - Seitsonen, Jani

AU - Ruokolainen, Janne

AU - Piras, Cristian

AU - Cramer, Rainer

AU - Edwards-Gayle, Charlotte J.C.

AU - Hamley, Ian W.

PY - 2020/10/14

Y1 - 2020/10/14

N2 - The designed arginine-rich surfactant-like peptide R3L12(arginine3-leucine12) is shown to form a remarkable diversity of self-assembled nanostructures in aqueous solution, depending on pH, including nanotubes, mesh-like tubular networks in three-dimensions and square planar arrays in two-dimensions. These structures are built from α-helical antiparallel coiled-coil peptide dimers arranged perpendicular to the nanotube axis, in a “cross-α” nanotube structure. The aggregation behavior is rationalized based on the effects of dimensionality, and the balance of hydrophobic and electrostatic interactions. The nanotube and nanomesh structures display arginine at high density on their surfaces, which may be valuable for future applications.

AB - The designed arginine-rich surfactant-like peptide R3L12(arginine3-leucine12) is shown to form a remarkable diversity of self-assembled nanostructures in aqueous solution, depending on pH, including nanotubes, mesh-like tubular networks in three-dimensions and square planar arrays in two-dimensions. These structures are built from α-helical antiparallel coiled-coil peptide dimers arranged perpendicular to the nanotube axis, in a “cross-α” nanotube structure. The aggregation behavior is rationalized based on the effects of dimensionality, and the balance of hydrophobic and electrostatic interactions. The nanotube and nanomesh structures display arginine at high density on their surfaces, which may be valuable for future applications.

UR - http://www.scopus.com/inward/record.url?scp=85092337809&partnerID=8YFLogxK

U2 - 10.1039/d0cc04299d

DO - 10.1039/d0cc04299d

M3 - Article

C2 - 33033814

AN - SCOPUS:85092337809

SN - 1359-7345

VL - 56

SP - 11977

EP - 11980

JO - Chemical Communications

JF - Chemical Communications

IS - 80

ER -

Peptide nanotubes self-assembled from leucine-rich alpha helical surfactant-like peptides

Abstract

Access to Document

Other files and links

Fingerprint

Cite this