Peptide Backbone Modifications

Research output: Contribution to journalReview ArticleScientificpeer-review

Researchers

Research units

  • Saarland University

Abstract

The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and CO-thionation are described.

Details

Original languageEnglish
Pages (from-to)355-385
Number of pages31
JournalCURRENT ORGANIC CHEMISTRY
Volume12
Issue number5
Publication statusPublished - Mar 2008
MoE publication typeA2 Review article in a scientific journal

ID: 11164106