Peptide Backbone Modifications

Jan Deska; Uli Kazmaier

doi:10.2174/138527208783743697

Peptide Backbone Modifications

Jan Deska, Uli Kazmaier

Not published at Aalto University

Saarland University

Research output: Contribution to journal › Review Article › peer-review

51 Citations (Scopus)

Abstract

The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and CO-thionation are described.

Original language	English
Pages (from-to)	355-385
Number of pages	31
Journal	Current Organic Chemistry
Volume	12
Issue number	5
DOIs	https://doi.org/10.2174/138527208783743697
Publication status	Published - Mar 2008
MoE publication type	A2 Review article, Literature review, Systematic review

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10.2174/138527208783743697

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abstract = "The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and CO-thionation are described. ",

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AB - The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and CO-thionation are described.

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DO - 10.2174/138527208783743697

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JO - Current Organic Chemistry

JF - Current Organic Chemistry

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Peptide Backbone Modifications

Abstract

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