Pantothenic Acid

Jesus Gonzalez-Lopez*, Luis Aliaga, Alejandro Gonzalez-Martinez, Maria V. Martinez-Toledo

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

3 Citations (Scopus)

Abstract

Pantothenic acid, also known as pantothenate or vitamin B5, is a water-soluble B-complex vitamin. It is pantoic acid linked to β-alanine through an amide bond. Pantothenic acid is of biologic importance because of its incorporation into coenzyme A (CoA) and acyl carrier protein (ACP), on which acetylation and acylation, respectively, and other interactions depend. Acyl-CoA synthetases activate fatty acids through a process that is energy dependent and requires adenosine triphosphate (ATP) and CoA. Most plants and microorganisms accomplish biosynthesis of pantothenic acid by enzymatically combining pantoic acid with β-alanine. Pantothenyl alcohol is used as a source of pantothenate activity for pharmaceutical vitamin products. Pantethine, the disulfide of pantetheine and CoA are also used as pharmaceutical products in several countries. They have been suggested to be effective in reducing cholesterol levels, curing fatty liver and treating related diseases.

Original languageEnglish
Title of host publicationIndustrial Biotechnology of Vitamins, Biopigments, and Antioxidants
PublisherWiley
Pages67-102
Number of pages36
ISBN (Electronic)9783527681754
ISBN (Print)9783527337347
DOIs
Publication statusPublished - 29 Apr 2016
MoE publication typeA3 Part of a book or another research book

Keywords

  • Acetylation
  • Acyl carrier protein
  • Acylation
  • Adenosine triphosphate
  • Coenzyme A
  • Pantothenate biosynthesis
  • Pantothenic acid
  • Pharmaceutical vitamin products

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