Oxidative stress in cancer cell metabolism

Saniya Arfin, Niraj Kumar Jha, Saurabh Kumar Jha, Kavindra Kumar Kesari, Janne Ruokolainen, Shubhadeep Roychoudhury, Brijesh Rathi, Dhruv Kumar*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

1 Citation (Scopus)
2 Downloads (Pure)

Abstract

Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers. Several studies have been found to be marked with increased ROS production which activates pro-tumorigenic signaling, enhances cell survival and proliferation and drives DNA damage and genetic instability. However, higher ROS levels have been found to promote anti-tumorigenic signaling by initiating oxidative stress-induced tumor cell death. Tumor cells develop a mechanism where they adjust to the high ROS by expressing elevated levels of antioxidant proteins to detoxify them while maintaining pro-tumorigenic signaling and resistance to apoptosis. Therefore, ROS manipulation can be a potential target for cancer therapies as cancer cells present an altered redox balance in comparison to their normal counterparts. In this review, we aim to provide an overview of the generation and sources of ROS within tumor cells, ROS-associated signaling pathways, their regulation by antioxidant defense systems, as well as the effect of elevated ROS production in tumor progression. It will provide an insight into how pro-and anti-tumorigenic ROS signaling pathways could be manipulated during the treatment of cancer.

Original languageEnglish
Article number642
Number of pages28
JournalAntioxidants
Volume10
Issue number5
DOIs
Publication statusPublished - 2021
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Angiogenesis
  • Apoptosis
  • Autophagy
  • Cancer metabolism
  • Drug resistance
  • Metastasis
  • Mitochondrial ROS
  • NFκB pathway
  • Oxidative stress
  • Tumor adaptation
  • Tumor pro-gression
  • Tumor targeting
  • Warburg effect

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