Opioidergic regulation of emotional arousal: A combined PET–fMRI study

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Opioidergic regulation of emotional arousal: A combined PET–fMRI study. / Karjalainen, Tomi; Seppälä, Kerttu; Glerean, Enrico; Karlsson, Henry K.; Lahnakoski, Juha; Nuutila, Pirjo; Jääskeläinen, Iiro; Hari, Riitta; Sams, Mikko; Nummenmaa, Lauri.

In: Cerebral Cortex, Vol. 29, No. 9, 09.2019, p. 4006–4016.

Research output: Contribution to journalArticle

Harvard

Karjalainen, T, Seppälä, K, Glerean, E, Karlsson, HK, Lahnakoski, J, Nuutila, P, Jääskeläinen, I, Hari, R, Sams, M & Nummenmaa, L 2019, 'Opioidergic regulation of emotional arousal: A combined PET–fMRI study', Cerebral Cortex, vol. 29, no. 9, pp. 4006–4016. https://doi.org/10.1093/cercor/bhy281

APA

Karjalainen, T., Seppälä, K., Glerean, E., Karlsson, H. K., Lahnakoski, J., Nuutila, P., ... Nummenmaa, L. (2019). Opioidergic regulation of emotional arousal: A combined PET–fMRI study. Cerebral Cortex, 29(9), 4006–4016. https://doi.org/10.1093/cercor/bhy281

Vancouver

Karjalainen T, Seppälä K, Glerean E, Karlsson HK, Lahnakoski J, Nuutila P et al. Opioidergic regulation of emotional arousal: A combined PET–fMRI study. Cerebral Cortex. 2019 Sep;29(9):4006–4016. https://doi.org/10.1093/cercor/bhy281

Author

Karjalainen, Tomi ; Seppälä, Kerttu ; Glerean, Enrico ; Karlsson, Henry K. ; Lahnakoski, Juha ; Nuutila, Pirjo ; Jääskeläinen, Iiro ; Hari, Riitta ; Sams, Mikko ; Nummenmaa, Lauri. / Opioidergic regulation of emotional arousal: A combined PET–fMRI study. In: Cerebral Cortex. 2019 ; Vol. 29, No. 9. pp. 4006–4016.

Bibtex - Download

@article{726bb58065034dc29b3205e36d5bc6bd,
title = "Opioidergic regulation of emotional arousal: A combined PET–fMRI study",
abstract = "Emotions can be characterized by dimensions of arousal and valence (pleasantness). While the functional brain bases of emotional arousal and valence have been actively investigated, the neuromolecular underpinnings remain poorly understood. We tested whether the opioid and dopamine systems involved in reward and motivational processes would be associated with emotional arousal and valence. We used in vivo positron emission tomography to quantify μ-opioid receptor and type 2 dopamine receptor (MOR and D2R, respectively) availability in brains of 35 healthy adult females. During subsequent functional magnetic resonance imaging carried out to monitor hemodynamic activity, the subjects viewed movie scenes of varying emotional content. Arousal and valence were associated with hemodynamic activity in brain regions involved in emotional processing, including amygdala, thalamus, and superior temporal sulcus. Cerebral MOR availability correlated negatively with the hemodynamic responses to arousing scenes in amygdala, hippocampus,thalamus, and hypothalamus, whereas no positive correlations were observed in any brain region. D2R availability—here reliably quantified only in striatum—was not associated with either arousal or valence. These results suggest that emotional arousal is regulated by the MOR system, and that cerebral MOR availability influences brain activity elicited by arousing stimuli.",
keywords = "dopamine, fMRI, PET, neurotransmitters, receptor",
author = "Tomi Karjalainen and Kerttu Sepp{\"a}l{\"a} and Enrico Glerean and Karlsson, {Henry K.} and Juha Lahnakoski and Pirjo Nuutila and Iiro J{\"a}{\"a}skel{\"a}inen and Riitta Hari and Mikko Sams and Lauri Nummenmaa",
year = "2019",
month = "9",
doi = "10.1093/cercor/bhy281",
language = "English",
volume = "29",
pages = "4006–4016",
journal = "Cerebral Cortex",
issn = "1047-3211",
number = "9",

}

RIS - Download

TY - JOUR

T1 - Opioidergic regulation of emotional arousal: A combined PET–fMRI study

AU - Karjalainen, Tomi

AU - Seppälä, Kerttu

AU - Glerean, Enrico

AU - Karlsson, Henry K.

AU - Lahnakoski, Juha

AU - Nuutila, Pirjo

AU - Jääskeläinen, Iiro

AU - Hari, Riitta

AU - Sams, Mikko

AU - Nummenmaa, Lauri

PY - 2019/9

Y1 - 2019/9

N2 - Emotions can be characterized by dimensions of arousal and valence (pleasantness). While the functional brain bases of emotional arousal and valence have been actively investigated, the neuromolecular underpinnings remain poorly understood. We tested whether the opioid and dopamine systems involved in reward and motivational processes would be associated with emotional arousal and valence. We used in vivo positron emission tomography to quantify μ-opioid receptor and type 2 dopamine receptor (MOR and D2R, respectively) availability in brains of 35 healthy adult females. During subsequent functional magnetic resonance imaging carried out to monitor hemodynamic activity, the subjects viewed movie scenes of varying emotional content. Arousal and valence were associated with hemodynamic activity in brain regions involved in emotional processing, including amygdala, thalamus, and superior temporal sulcus. Cerebral MOR availability correlated negatively with the hemodynamic responses to arousing scenes in amygdala, hippocampus,thalamus, and hypothalamus, whereas no positive correlations were observed in any brain region. D2R availability—here reliably quantified only in striatum—was not associated with either arousal or valence. These results suggest that emotional arousal is regulated by the MOR system, and that cerebral MOR availability influences brain activity elicited by arousing stimuli.

AB - Emotions can be characterized by dimensions of arousal and valence (pleasantness). While the functional brain bases of emotional arousal and valence have been actively investigated, the neuromolecular underpinnings remain poorly understood. We tested whether the opioid and dopamine systems involved in reward and motivational processes would be associated with emotional arousal and valence. We used in vivo positron emission tomography to quantify μ-opioid receptor and type 2 dopamine receptor (MOR and D2R, respectively) availability in brains of 35 healthy adult females. During subsequent functional magnetic resonance imaging carried out to monitor hemodynamic activity, the subjects viewed movie scenes of varying emotional content. Arousal and valence were associated with hemodynamic activity in brain regions involved in emotional processing, including amygdala, thalamus, and superior temporal sulcus. Cerebral MOR availability correlated negatively with the hemodynamic responses to arousing scenes in amygdala, hippocampus,thalamus, and hypothalamus, whereas no positive correlations were observed in any brain region. D2R availability—here reliably quantified only in striatum—was not associated with either arousal or valence. These results suggest that emotional arousal is regulated by the MOR system, and that cerebral MOR availability influences brain activity elicited by arousing stimuli.

KW - dopamine

KW - fMRI

KW - PET

KW - neurotransmitters

KW - receptor

U2 - 10.1093/cercor/bhy281

DO - 10.1093/cercor/bhy281

M3 - Article

VL - 29

SP - 4006

EP - 4016

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 9

ER -

ID: 29817839