On the role of API in determining porosity, pore structure and bulk modulus of the skeletal material in pharmaceutical tablets formed with MCC as sole excipient

Research output: Contribution to journalArticleScientificpeer-review

Researchers

  • Cathy Ridgway
  • Prince Bawuah
  • Daniel Markl
  • J. Axel Zeitler
  • Jarkko Ketolainen
  • Kai-Erik Peiponen
  • Patrick Gane

Research units

  • Omya International AG
  • University of Eastern Finland
  • University of Cambridge

Abstract

The physical properties and mechanical integrity of pharmaceutical tablets are of major importance when loading with active pharmaceutical ingredient(s) (API) in order to ensure ease of processing, control of dosage and stability during transportation and handling prior to patient consumption. The interaction between API and excipient, acting as functional extender and binder, however, is little understood in this context. The API indomethacin is combined in this study with microcrystalline cellulose (MCC) at increasing loading levels. Tablets from the defined API/MCC ratios are made under conditions of controlled porosity and tablet thickness, resulting from different compression conditions, and thus compaction levels. Mercury intrusion porosimetry is used to establish the accessible pore volume, pore size distribution and, adopting the observed region of elastic intrusion-extrusion at high pressure, an elastic bulk modulus of the skeletal material is recorded. Porosity values are compared to previously published values derived from terahertz (THz) refractive index data obtained from exactly the same tablet sample sets. It is shown that the elastic bulk modulus is dependent on API wt% loading under constant tablet preparation conditions delivering equal dimensions and porosity. The findings are considered of novel value in respect to establishing consistency of tablet production and optimisation of physical properties.

Details

Original languageEnglish
Pages (from-to)321-331
Number of pages11
JournalInternational Journal of Pharmaceutics
Volume526
Issue number1-2
Publication statusPublished - 30 Jun 2017
MoE publication typeA1 Journal article-refereed

    Research areas

  • API impact on tablet structure, Excipient-API interactions, Mechanical properties of compacts, Pharmaceutical tableting, Pore network analysis, Tablet porosity, Terahertz measurements

ID: 13368226