On the lipase-catalyzed resolution of functionalized biaryls

Jan Deska, Benedikt Skrobo

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The implementation of lipase catalysis as a tool for the preparation of optically active biaryls is discussed. While attempts toward dynamic kinetic resolution based on the catalytic ring opening of configurationally unstable biaryl lactones were fruitless, kinetic resolution via transesterification of hydroxymethyl-decorated substrates was successfully employed in the generation of optically enriched, axially chiral biaryls.
Original languageEnglish
Pages (from-to)1052-1056
Number of pages5
JournalTETRAHEDRON-ASYMMETRY
Volume24
Issue number17
DOIs
Publication statusPublished - 15 Sep 2013
MoE publication typeA1 Journal article-refereed

Keywords

  • biaryls
  • atropisomerism
  • lipase
  • biocatalysis
  • kinetic resolution

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