Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation

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Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation. / Camara, Carmen; Subramaniyam, Narayan P.; Warwick, Kevin; Parkkonen, Lauri; Aziz, Tipu; Pereda, Ernesto.

In: Sensors (Basel, Switzerland), Vol. 19, No. 11, 2507, 01.06.2019.

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@article{d322ebb7e7704c848a69f2bf0b607e37,
title = "Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation",
abstract = "Parkinson's Disease (PD) is currently the second most common neurodegenerative disease. One of the most characteristic symptoms of PD is resting tremor. Local Field Potentials (LFPs) have been widely studied to investigate deviations from the typical patterns of healthy brain activity. However, the inherent dynamics of the Sub-Thalamic Nucleus (STN) LFPs and their spatiotemporal dynamics have not been well characterized. In this work, we study the non-linear dynamical behaviour of STN-LFPs of Parkinsonian patients using ε -recurrence networks. RNs are a non-linear analysis tool that encodes the geometric information of the underlying system, which can be characterised (for example, using graph theoretical measures) to extract information on the geometric properties of the attractor. Results show that the activity of the STN becomes more non-linear during the tremor episodes and that ε -recurrence network analysis is a suitable method to distinguish the transitions between movement conditions, anticipating the onset of the tremor, with the potential for application in a demand-driven deep brain stimulation system.",
keywords = "Deep Brain Stimulation (DBS), Local Field Potentials (LFPs), nonlinear dynamics, Parkinson’s Disease (PD), Recurrence Networks (RNs), Support Vector Machine (SVM)",
author = "Carmen Camara and Subramaniyam, {Narayan P.} and Kevin Warwick and Lauri Parkkonen and Tipu Aziz and Ernesto Pereda",
year = "2019",
month = "6",
day = "1",
doi = "10.3390/s19112507",
language = "English",
volume = "19",
journal = "Sensors",
issn = "1424-8220",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

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TY - JOUR

T1 - Non-Linear Dynamical Analysis of Resting Tremor for Demand-Driven Deep Brain Stimulation

AU - Camara, Carmen

AU - Subramaniyam, Narayan P.

AU - Warwick, Kevin

AU - Parkkonen, Lauri

AU - Aziz, Tipu

AU - Pereda, Ernesto

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Parkinson's Disease (PD) is currently the second most common neurodegenerative disease. One of the most characteristic symptoms of PD is resting tremor. Local Field Potentials (LFPs) have been widely studied to investigate deviations from the typical patterns of healthy brain activity. However, the inherent dynamics of the Sub-Thalamic Nucleus (STN) LFPs and their spatiotemporal dynamics have not been well characterized. In this work, we study the non-linear dynamical behaviour of STN-LFPs of Parkinsonian patients using ε -recurrence networks. RNs are a non-linear analysis tool that encodes the geometric information of the underlying system, which can be characterised (for example, using graph theoretical measures) to extract information on the geometric properties of the attractor. Results show that the activity of the STN becomes more non-linear during the tremor episodes and that ε -recurrence network analysis is a suitable method to distinguish the transitions between movement conditions, anticipating the onset of the tremor, with the potential for application in a demand-driven deep brain stimulation system.

AB - Parkinson's Disease (PD) is currently the second most common neurodegenerative disease. One of the most characteristic symptoms of PD is resting tremor. Local Field Potentials (LFPs) have been widely studied to investigate deviations from the typical patterns of healthy brain activity. However, the inherent dynamics of the Sub-Thalamic Nucleus (STN) LFPs and their spatiotemporal dynamics have not been well characterized. In this work, we study the non-linear dynamical behaviour of STN-LFPs of Parkinsonian patients using ε -recurrence networks. RNs are a non-linear analysis tool that encodes the geometric information of the underlying system, which can be characterised (for example, using graph theoretical measures) to extract information on the geometric properties of the attractor. Results show that the activity of the STN becomes more non-linear during the tremor episodes and that ε -recurrence network analysis is a suitable method to distinguish the transitions between movement conditions, anticipating the onset of the tremor, with the potential for application in a demand-driven deep brain stimulation system.

KW - Deep Brain Stimulation (DBS)

KW - Local Field Potentials (LFPs)

KW - nonlinear dynamics

KW - Parkinson’s Disease (PD)

KW - Recurrence Networks (RNs)

KW - Support Vector Machine (SVM)

UR - http://www.scopus.com/inward/record.url?scp=85067186586&partnerID=8YFLogxK

U2 - 10.3390/s19112507

DO - 10.3390/s19112507

M3 - Article

VL - 19

JO - Sensors

JF - Sensors

SN - 1424-8220

IS - 11

M1 - 2507

ER -

ID: 35182448