Neuronal subserving of behavior before and after chronic ethanol treatment

Yu I. Alexandrov*, Yu V. Grinchenko, M. V. Bodunov, V. N. Matz, A. V. Korpusova, S. Laukka, M. Sams

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Abstract

We have previously shown that an acute ethanol dose (1 g/kg), sufficient to impair the performance of a healthy rabbit, also reversibly depresses the activity of those limbic-cortex neurons that are specifically activated during recently learned behavioral acts. Our new morphological and neurophysiological data suggest a death of such neurons after 9-month chronic ethanol treatment. The effect of acute ethanol administration on neurons and performance speed in alcoholic rabbits was opposite to that found in healthy animals. Our results help to understand why neurocognition of alcoholics changes and why acute low-level alcohol ingestion influences them differently than healthy individuals. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalAlcohol
Volume22
Issue number2
DOIs
Publication statusPublished - Oct 2000
MoE publication typeA1 Journal article-refereed

Keywords

  • Behavior
  • Cingulate cortex
  • Ethanol
  • Neuron

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