Neural Substrate for Metacognitive Accuracy of Tactile Working Memory

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Neural Substrate for Metacognitive Accuracy of Tactile Working Memory. / Gogulski, Juha; Zetter, Rasmus; Nyrhinen, Mikko; Pertovaara, Antti; Carlson, Synnove.

In: Cerebral Cortex, Vol. 27, No. 11, 11.2017, p. 5343-5352.

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@article{3af3fa3482a9459b976da47949e40cd0,
title = "Neural Substrate for Metacognitive Accuracy of Tactile Working Memory",
abstract = "The human prefrontal cortex (PFC) has been shown to be important for metacognition, the capacity to monitor and control one's own cognitive processes. Here we dissected the neural architecture of somatosensory metacognition using navigated single-pulse transcranial magnetic stimulation (TMS) to modulate tactile working memory (WM) processing. We asked subjects to perform tactile WM tasks and to give a confidence rating for their performance after each trial. We circumvented the challenge of interindividual variability in functional brain anatomy by applying TMS to two PFC areas that, according to tractography, were neurally connected with the primary somatosensory cortex (S1): one area in the superior frontal gyrus (SFG), another in the middle frontal gyrus (MFG). These two PFC locations and a control cortical area were stimulated during both spatial and temporal tactile WM tasks. We found that tractography-guided TMS of the SFG area selectively enhanced metacognitive accuracy of tactile temporal, but not spatial WM. Stimulation of the MFG area that was also neurally connected with the S1 had no such effect on metacognitive accuracy of either the temporal or spatial tactile WM. Our findings provide causal evidence that the PFC contains distinct neuroanatomical substrates for introspective accuracy of tactile WM.",
keywords = "metacognition, TMS, tractography, working memory, TRANSCRANIAL MAGNETIC STIMULATION, VENTROLATERAL PREFRONTAL CORTEX, PRIMARY SOMATOSENSORY CORTEX, DECISION-MAKING, CEREBRAL-CORTEX, HUMAN BRAIN, PERCEPTUAL CONFIDENCE, FRONTAL-CORTEX, DISCRIMINATION, VARIABILITY",
author = "Juha Gogulski and Rasmus Zetter and Mikko Nyrhinen and Antti Pertovaara and Synnove Carlson",
year = "2017",
month = "11",
doi = "10.1093/cercor/bhx219",
language = "English",
volume = "27",
pages = "5343--5352",
journal = "Cerebral Cortex",
issn = "1047-3211",
number = "11",

}

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TY - JOUR

T1 - Neural Substrate for Metacognitive Accuracy of Tactile Working Memory

AU - Gogulski, Juha

AU - Zetter, Rasmus

AU - Nyrhinen, Mikko

AU - Pertovaara, Antti

AU - Carlson, Synnove

PY - 2017/11

Y1 - 2017/11

N2 - The human prefrontal cortex (PFC) has been shown to be important for metacognition, the capacity to monitor and control one's own cognitive processes. Here we dissected the neural architecture of somatosensory metacognition using navigated single-pulse transcranial magnetic stimulation (TMS) to modulate tactile working memory (WM) processing. We asked subjects to perform tactile WM tasks and to give a confidence rating for their performance after each trial. We circumvented the challenge of interindividual variability in functional brain anatomy by applying TMS to two PFC areas that, according to tractography, were neurally connected with the primary somatosensory cortex (S1): one area in the superior frontal gyrus (SFG), another in the middle frontal gyrus (MFG). These two PFC locations and a control cortical area were stimulated during both spatial and temporal tactile WM tasks. We found that tractography-guided TMS of the SFG area selectively enhanced metacognitive accuracy of tactile temporal, but not spatial WM. Stimulation of the MFG area that was also neurally connected with the S1 had no such effect on metacognitive accuracy of either the temporal or spatial tactile WM. Our findings provide causal evidence that the PFC contains distinct neuroanatomical substrates for introspective accuracy of tactile WM.

AB - The human prefrontal cortex (PFC) has been shown to be important for metacognition, the capacity to monitor and control one's own cognitive processes. Here we dissected the neural architecture of somatosensory metacognition using navigated single-pulse transcranial magnetic stimulation (TMS) to modulate tactile working memory (WM) processing. We asked subjects to perform tactile WM tasks and to give a confidence rating for their performance after each trial. We circumvented the challenge of interindividual variability in functional brain anatomy by applying TMS to two PFC areas that, according to tractography, were neurally connected with the primary somatosensory cortex (S1): one area in the superior frontal gyrus (SFG), another in the middle frontal gyrus (MFG). These two PFC locations and a control cortical area were stimulated during both spatial and temporal tactile WM tasks. We found that tractography-guided TMS of the SFG area selectively enhanced metacognitive accuracy of tactile temporal, but not spatial WM. Stimulation of the MFG area that was also neurally connected with the S1 had no such effect on metacognitive accuracy of either the temporal or spatial tactile WM. Our findings provide causal evidence that the PFC contains distinct neuroanatomical substrates for introspective accuracy of tactile WM.

KW - metacognition

KW - TMS

KW - tractography

KW - working memory

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - VENTROLATERAL PREFRONTAL CORTEX

KW - PRIMARY SOMATOSENSORY CORTEX

KW - DECISION-MAKING

KW - CEREBRAL-CORTEX

KW - HUMAN BRAIN

KW - PERCEPTUAL CONFIDENCE

KW - FRONTAL-CORTEX

KW - DISCRIMINATION

KW - VARIABILITY

U2 - 10.1093/cercor/bhx219

DO - 10.1093/cercor/bhx219

M3 - Article

VL - 27

SP - 5343

EP - 5352

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 11

ER -

ID: 16139604