Natural Shape-Retaining Microcapsules With Shells Made of Chitosan-Coated Colloidal Lignin Particles

Tao Zou, Mika Sipponen, Monika Österberg

Research output: Contribution to journalArticleScientificpeer-review

7 Citations (Scopus)
79 Downloads (Pure)

Abstract

Thin film coating of charged nanoparticles with oppositely charged polymers is an efficient and straightforward way for surface modification, but synthetic polyelectrolytes should be replaced by abundant biopolymers. In this study a thin film of chitosan was adsorbed onto colloidal lignin particles (CLPs) that were then systematically studied for olive oil stabilization with an objective to develop shape-retaining microcapsules that comprised of only renewable biomaterials. Full surface coverage was achieved with merely 5 wt% of chitosan relative to the dry weight of CLPs, reversing their surface charge from negative to positive. Such modification rendered the chitosan-coated particles excellent stabilizers for forming Pickering emulsions with olive oil. The emulsion droplets could be further stabilized by sodium triphosphate that provided ionic intra- and inter-particle cross-linking of the chitosan corona on the CLPs. Following the optimum conditions, the non-cross-linked microcapsules exhibited a strong stability against coalescence and the electrostatically stabilized ones additionally retained their shape upon drying and rewetting. Non-cross-linked microcapsules were used to demonstrate encapsulation and rapid release of ciprofloxacin as a model lipophilic drug in aqueous media. Overall, the combination of antimicrobial chitosan and antioxidative lignin nanoparticles hold unprecedented opportunities as biocompatible and biodegradable materials for controlled drug delivery.
Original languageEnglish
Article number370
Number of pages12
JournalFrontiers in Chemistry
Volume7
Issue numberMAY
DOIs
Publication statusPublished - 1 Jan 2019
MoE publication typeA1 Journal article-refereed

Keywords

  • Chitosan
  • Drug delivery
  • Lignin nanoparticles
  • Microcapsule
  • Pickering emulsion
  • Thin film coating

Fingerprint Dive into the research topics of 'Natural Shape-Retaining Microcapsules With Shells Made of Chitosan-Coated Colloidal Lignin Particles'. Together they form a unique fingerprint.

  • Projects

    SUSCELL - Sustainable Composites through Enzymatic processing of Lignin and Lipids

    Zhang, X., Österberg, M., Zou, T., Johansson, L., Kimiaei, E. & Grande, R.

    31/12/201731/12/2020

    Project: Other external funding: Other foreign funding

    Equipment

  • Cite this