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Abstract
Nanoswimmers are synthetic nanoscale objects that convert the available surrounding free energy to a directed motion. For example, bacteria with various flagella types serve as textbook examples of the minuscule swimmers found in nature. Along these lines, a plethora of artificial hybrid and non-hybrid nanoswimmers have been introduced, and they could find many uses, e.g., for targeted drug delivery systems (TDDSs) and controlled drug treatments. Here, we discuss a certain class of nanoparticles, i.e., functional, capped Janus nanospheres that can be employed as nanoswimmers, their subclasses and properties, as well as their various implementations. A brief outlook is given on different fabrication and synthesis methods, as well as on the diverse compositions used to prepare nanoswimmers, with a focus on the particle types and materials suitable for biomedical applications. Several recent studies have shown remarkable success in achieving temporally and spatially controlled drug delivery in vitro using Janus-particle-based TDDSs. We believe that this review will serve as a concise introductory synopsis for the interested readers. Therefore, we hope that it will deepen the general understanding of nanoparticle behavior in biological matrices.
Original language | English |
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Article number | 4442 |
Journal | Materials |
Volume | 15 |
Issue number | 13 |
Early online date | 24 Jun 2022 |
DOIs | |
Publication status | Published - 1 Jul 2022 |
MoE publication type | A2 Review article, Literature review, Systematic review |
Keywords
- biohybrids
- biomedicine
- Janus particles
- nanofabrication
- nanospheres
- nanoswimmers
- targeted delivery
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Dive into the research topics of 'Nanoswimmers Based on Capped Janus Nanospheres'. Together they form a unique fingerprint.Projects
- 1 Finished
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LIBER Kostiainen: Life-like hybrid materials Kostiainen
Kostiainen, M. (Principal investigator), George, L. (Project Member), Luotonen, O. (Project Member), Zhou, Y. (Project Member), Wierzchowiecka, J. (Project Member), Saarinen, S. (Project Member) & D'Amico, C. (Project Member)
01/01/2022 → 31/12/2024
Project: Academy of Finland: Other research funding