Abstract
Various techniques have been developed to produce second generation biomaterials for tissue repair. These include extrusion, molding, salt leaching, spinning etc, but success in regenerating tissues has been limited. It is important to develop porous material, yet with a fibrous structure for it to be biomimetic. To mimic biological tissues, the extra-cellular matrix usually contains fibers in nano scale. To produce nanostructures, self-assembly or electrospinning can be used. Adding a drug release function to such a material may advance applications further for use in controlled tissue repair. This turns the resulting device into a multifunctional porous, fibrous structure to support cells and drug releasing properties in order to control tissue reactions. A bioabsorbable poly(ε-caprolactone-co-D,L lactide) 95/5 (PCL) was made into diluted solution using a solvent, to which was added 2w-% of diclofenac sodium (DS). Nano-fibers were made by electrospinning onto substrate. Microstructure of the resulting nanomat was studied using SEM and drug release profiles with UV/VIS spectroscopy. Thickness of the electrospun nanomat was about 2 mm. SEM analysis showed that polymeric nano-fibers containing drug particles form a highly interconnected porous nano structure. Average diameter of the nano-fibers was 130 nm. There was a high burst peak in drug release, which decreased to low levels after one day. The used polymer has slow a degradation rate and though the nanomat was highly porous with a large surface area, drug release rate is slow. It is feasible to develop a nano-fibrous porous structure of bioabsorbable polymer, which is loaded with test drug. Drug release is targeted at improving the properties of biomaterial for use in controlled tissue repair and regeneration.
Original language | English |
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Title of host publication | AIP Conference Proceedings |
Pages | 901-906 |
Number of pages | 6 |
Volume | 973 |
DOIs | |
Publication status | Published - 2008 |
MoE publication type | A4 Conference publication |
Event | International Conference on Multiscale and Functionally Graded Materials - Oahu, HI, United States Duration: 15 Oct 2006 → 18 Oct 2006 Conference number: 9 |
Publication series
Name | AIP Conference Proceedings, MULTISCALE AND FUNCTIONALLY GRADED MATERIALS |
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Volume | 973 |
Conference
Conference | International Conference on Multiscale and Functionally Graded Materials |
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Country/Territory | United States |
City | Oahu, HI |
Period | 15/10/2006 → 18/10/2006 |
Keywords
- Drug release
- Electrospinning
- Nano-fibers