Nanostructured diclofenac sodium releasing material

L. Nikkola*, K. Vapalahti, A. Harlin, Jukka Seppälä, N. Ashammakhi

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

    2 Citations (Scopus)

    Abstract

    Various techniques have been developed to produce second generation biomaterials for tissue repair. These include extrusion, molding, salt leaching, spinning etc, but success in regenerating tissues has been limited. It is important to develop porous material, yet with a fibrous structure for it to be biomimetic. To mimic biological tissues, the extra-cellular matrix usually contains fibers in nano scale. To produce nanostructures, self-assembly or electrospinning can be used. Adding a drug release function to such a material may advance applications further for use in controlled tissue repair. This turns the resulting device into a multifunctional porous, fibrous structure to support cells and drug releasing properties in order to control tissue reactions. A bioabsorbable poly(ε-caprolactone-co-D,L lactide) 95/5 (PCL) was made into diluted solution using a solvent, to which was added 2w-% of diclofenac sodium (DS). Nano-fibers were made by electrospinning onto substrate. Microstructure of the resulting nanomat was studied using SEM and drug release profiles with UV/VIS spectroscopy. Thickness of the electrospun nanomat was about 2 mm. SEM analysis showed that polymeric nano-fibers containing drug particles form a highly interconnected porous nano structure. Average diameter of the nano-fibers was 130 nm. There was a high burst peak in drug release, which decreased to low levels after one day. The used polymer has slow a degradation rate and though the nanomat was highly porous with a large surface area, drug release rate is slow. It is feasible to develop a nano-fibrous porous structure of bioabsorbable polymer, which is loaded with test drug. Drug release is targeted at improving the properties of biomaterial for use in controlled tissue repair and regeneration.

    Original languageEnglish
    Title of host publicationAIP Conference Proceedings
    Pages901-906
    Number of pages6
    Volume973
    DOIs
    Publication statusPublished - 2008
    MoE publication typeA4 Article in a conference publication
    EventInternational Conference on Multiscale and Functionally Graded Materials - Oahu, HI, United States
    Duration: 15 Oct 200618 Oct 2006
    Conference number: 9

    Publication series

    NameAIP Conference Proceedings, MULTISCALE AND FUNCTIONALLY GRADED MATERIALS
    Volume973

    Conference

    ConferenceInternational Conference on Multiscale and Functionally Graded Materials
    Country/TerritoryUnited States
    CityOahu, HI
    Period15/10/200618/10/2006

    Keywords

    • Drug release
    • Electrospinning
    • Nano-fibers

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