Nanoparticulate RNA delivery systems in cancer

Ankur Sharma*, Niraj Kumar Jha, Kajal Dahiya, Vivek Kumar Singh, Kundan Chaurasiya, Aditya Narayan Jha, Saurabh Kumar Jha, Prabhu Chandra Mishra, Sunny Dholpuria, Rani Astya, Parma Nand, Amit Kumar, Janne Ruokolainen, Kavindra Kumar Kesari

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Background: Drug delivery system is a common practice in cancer treatment. RNA interference-mediated post-transcriptional gene silencing holds promise as an approach to knockdown in the expression of target genes responsible for cancer cell growth and metastasis. RNA interference (RNAi) can be achieved by delivering small interfering RNA (siRNA) and short hairpin RNA (shRNA) to target cells. Since neither interfering RNAs can be delivered in naked form due to poor stability, an efficient delivery system is required that protects, guides, and delivers the siRNA and shRNA to target cells as part of cancer therapy (chemotherapy). Recent findings: In this review, a discussion is presented about the different types of drug delivery system used to deliver siRNA and shRNA, together with an overview of the potential benefits associated with this sophisticated biomolecular therapy. Improved understanding of the different approaches used in nanoparticle (NP) fabrication, along with an enhanced appreciation of the biochemical properties of siRNA/shRNA, will assist in developing improved drug delivery strategies in basic and clinical research. Conclusion: These novel delivery techniques are able to solve the problems that form an inevitable part of delivering genes in more efficient manner and as part of more effective treatment protocols. The present review concludes that the nanoparticulate RNA delivery system has great possibility for cancer treatment along with several other proposed methods. Several NPs or nanocarriers are already in use, but the methods proposed here could fulfill the missing gap in cancer research. It is the future technology, which unravels the mystery of resolving genomic diseases that is, especially genomic instability and its signaling cascades.

Original languageEnglish
JournalCancer Reports
DOIs
Publication statusE-pub ahead of print - 1 Jan 2020
MoE publication typeA2 Review article in a scientific journal

Keywords

  • drug delivery
  • metastasis
  • Ran-GTP
  • RNAi
  • shRNA
  • siRNA

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    Sharma, A., Jha, N. K., Dahiya, K., Singh, V. K., Chaurasiya, K., Jha, A. N., Jha, S. K., Mishra, P. C., Dholpuria, S., Astya, R., Nand, P., Kumar, A., Ruokolainen, J., & Kesari, K. K. (2020). Nanoparticulate RNA delivery systems in cancer. Cancer Reports . https://doi.org/10.1002/cnr2.1271