Nanomaterials in Alzheimer's disease treatment: a comprehensive review

Maryam Faiyaz; Mohd Azhardin Ganayee; Salman Akhtar; Saravanan Krishnan; Bableen Flora; Deeksha Dogra; Niraj Kumar Jha; Dinesh Kumar Chellappan; Poonam Negi; Kamal Dua; Kavindra Kumar Kesari; Piyush Kumar Gupta

doi:10.52586/4992

Nanomaterials in Alzheimer's disease treatment: a comprehensive review

Maryam Faiyaz, Mohd Azhardin Ganayee, Salman Akhtar, Saravanan Krishnan, Bableen Flora, Deeksha Dogra, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua, Kavindra Kumar Kesari^*, Piyush Kumar Gupta

^*Corresponding author for this work

Department of Applied Physics

Research output: Contribution to journal › Review Article › peer-review

13 Citations (Scopus)

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Abstract

Alzheimer's, a progressive neurodegenerative disease affects brain and neurons through enormous reduction in nerve cell regenerative capacity. Dementia and impairment of cognitive functions are more prevalent in Alzheimer's disease (AD) patients in both industrialized and non-industrialized countries. Various factors play significant role in molecular cascades that leads to neuronal inflammation, dementia and thereby AD progression. Current medications are symptomatic that alleviates pain while lack in absolute cure, urging researchers to explore targets and therapeutics. Interestingly, nanomedicines developed due to the onset of nanotechnology, are being extensively investigated for the treatment of AD. This review presents the advancement in nanotherapeutic strategies, involving the emergence of nanomaterials that offers advantage to pass through the blood-brain barrier and acts as a therapeutic modality against AD.

Original language	English
Pages (from-to)	851-865
Number of pages	15
Journal	Frontiers in Bioscience - Landmark
Volume	26
Issue number	10
DOIs	https://doi.org/10.52586/4992
Publication status	Published - 30 Oct 2021
MoE publication type	A2 Review article, Literature review, Systematic review

Keywords

Alzheimer's disease
Dementia
Nanomaterials
Nanoparticles
Therapeutics

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10.52586/4992Licence: CC BY

Nanomaterials in Alzheimer's disease treatmentFinal published version, 4.17 MBLicence: CC BY

Cite this

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abstract = "Alzheimer's, a progressive neurodegenerative disease affects brain and neurons through enormous reduction in nerve cell regenerative capacity. Dementia and impairment of cognitive functions are more prevalent in Alzheimer's disease (AD) patients in both industrialized and non-industrialized countries. Various factors play significant role in molecular cascades that leads to neuronal inflammation, dementia and thereby AD progression. Current medications are symptomatic that alleviates pain while lack in absolute cure, urging researchers to explore targets and therapeutics. Interestingly, nanomedicines developed due to the onset of nanotechnology, are being extensively investigated for the treatment of AD. This review presents the advancement in nanotherapeutic strategies, involving the emergence of nanomaterials that offers advantage to pass through the blood-brain barrier and acts as a therapeutic modality against AD.",

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AU - Flora, Bableen

AU - Dogra, Deeksha

AU - Jha, Niraj Kumar

AU - Chellappan, Dinesh Kumar

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AU - Dua, Kamal

AU - Kesari, Kavindra Kumar

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AB - Alzheimer's, a progressive neurodegenerative disease affects brain and neurons through enormous reduction in nerve cell regenerative capacity. Dementia and impairment of cognitive functions are more prevalent in Alzheimer's disease (AD) patients in both industrialized and non-industrialized countries. Various factors play significant role in molecular cascades that leads to neuronal inflammation, dementia and thereby AD progression. Current medications are symptomatic that alleviates pain while lack in absolute cure, urging researchers to explore targets and therapeutics. Interestingly, nanomedicines developed due to the onset of nanotechnology, are being extensively investigated for the treatment of AD. This review presents the advancement in nanotherapeutic strategies, involving the emergence of nanomaterials that offers advantage to pass through the blood-brain barrier and acts as a therapeutic modality against AD.

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KW - Dementia

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Nanomaterials in Alzheimer's disease treatment: a comprehensive review

Abstract

Keywords

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