Nanomaterials in Alzheimer's disease treatment: a comprehensive review

Maryam Faiyaz, Mohd Azhardin Ganayee, Salman Akhtar, Saravanan Krishnan, Bableen Flora, Deeksha Dogra, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua, Kavindra Kumar Kesari*, Piyush Kumar Gupta

*Corresponding author for this work

Research output: Contribution to journalReview ArticleScientificpeer-review

1 Citation (Scopus)
12 Downloads (Pure)

Abstract

Alzheimer's, a progressive neurodegenerative disease affects brain and neurons through enormous reduction in nerve cell regenerative capacity. Dementia and impairment of cognitive functions are more prevalent in Alzheimer's disease (AD) patients in both industrialized and non-industrialized countries. Various factors play significant role in molecular cascades that leads to neuronal inflammation, dementia and thereby AD progression. Current medications are symptomatic that alleviates pain while lack in absolute cure, urging researchers to explore targets and therapeutics. Interestingly, nanomedicines developed due to the onset of nanotechnology, are being extensively investigated for the treatment of AD. This review presents the advancement in nanotherapeutic strategies, involving the emergence of nanomaterials that offers advantage to pass through the blood-brain barrier and acts as a therapeutic modality against AD.

Original languageEnglish
Pages (from-to)851-865
Number of pages15
JournalFrontiers in Bioscience - Landmark
Volume26
Issue number10
DOIs
Publication statusPublished - 30 Oct 2021
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Alzheimer's disease
  • Dementia
  • Nanomaterials
  • Nanoparticles
  • Therapeutics

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