Multi-material cellular structured orthopedic implants design: In vitro and bio-tribological performance

M. M. Costa*, R. Lima, N. Alves, N. A. Silva, M. Gasik, F. S. Silva, F. Bartolomeu, G. Miranda

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)
42 Downloads (Pure)


In this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to βTCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance.

Original languageEnglish
Article number105246
Number of pages16
JournalJournal of the Mechanical Behavior of Biomedical Materials
Early online date2 May 2022
Publication statusPublished - Jul 2022
MoE publication typeA1 Journal article-refereed


  • Bio-tribological experiments
  • In vitro
  • Multi-material structures
  • NiTi-Based
  • Ti6Al4V-based


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