MRI-compatible pneumatic stimulator for sensorimotor mapping

Research output: Contribution to journalArticleScientificpeer-review

Researchers

  • Valentina Lolli
  • Antonin Rovaï
  • Nicola Trotta
  • Mathieu Bourguignon
  • Serge Goldman
  • Niloufar Sadeghi
  • Veikko Jousmäki

  • Xavier De Tiège

Research units

  • Universite Libre de Bruxelles
  • ULB
  • Karolinska Institutet
  • Nanyang Technological University

Abstract

Background: Two major concerns with respect to task-based motor functional magnetic resonance imaging (fMRI) are inadequate participants’ performance as well as intra- and inter-subject variability in execution of the motor action. New method: This study validates the use of an MRI-compatible stimulator based on a pneumatic artificial muscle (PAM) for block-design fMRI mapping of the primary sensorimotor (SM1) cortex in a series of fifteen right-handed healthy subjects. The PAM stimulator elicits computer-controlled timely and reproducible passive movements of fingers/toes. Participants performed comparable active and passive PAM-induced flexion-extensions of the index fingers. Results: Passive movement of the right index finger and passive alternating right and left index finger movement resulted in a significant increase in blood-oxygen-level-dependent (BOLD) signal in contralateral SM1 cortex in 14/15 and 15/15 subjects respectively. Similar networks were recruited by active and passive index finger movements. However, at the group level, active movement induced significantly higher increases in BOLD signal than passive movement in contralateral SM1 cortex (p < 0.05 Family Wise Error [FWE] corrected), supplementary motor area (p < 0.001 uncorrected), ipsilateral cerebellum (p < 0.001 uncorrected), and bilateral putamina (p < 0.001 uncorrected). Comparison with existing method(s): As compared to the several MRI-compatible robotic devices for computer-controlled passive movement of the fingers that were introduced in the past decades, the proposed PAM-based stimulator is smaller, handier, and easier to use in the MRI setting. Conclusions: PAM-based stimulators can be reliably used for passive sensorimotor fMRI mapping in healthy subjects. Using this approach, bilateral SM1 cortices can be mapped accurately during a single 6-min block-design fMRI protocol.

Details

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalJournal of Neuroscience Methods
Volume313
Publication statusPublished - 1 Feb 2019
MoE publication typeA1 Journal article-refereed

    Research areas

  • Blood-oxygen-level-dependent (BOLD) signal, Functional magnetic resonance imaging (fMRI), Passive movement, Pneumatic artificial muscle (PAM), Robotic device, Sensorimotor system

ID: 31089507