Molecular mechanisms of interplay between autophagy and metabolism in cancer

Sibi Raj, Vaishali Chandel, Arun Kumar, Kavindra Kesari, Shailendra Asthana, Janne Ruokolainen, Mohammad Amjad Kamal, Dhruv Kumar*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

2 Citations (Scopus)

Abstract

Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how autophagy and cancer cells go hand in hand to support cancer cell progression. The important aspect in cancer and autophagy is the interdependence of autophagy in the survival and progression of cancer cells. Autophagy is known to be a major cause of chemotherapeutic resistance in various cancer cell types. Therefore, inhibition of autophagy as an effective therapeutic approach is being actively studied and tested in clinical studies. Multiple metabolic pathways are linked with autophagy that could potentially be a significant target for chemotherapeutic strategy. The comprehension of the interconnection of autophagy with cancer metabolism can pave a novel findings for effective combinatorial therapeutic strategies.
Original languageEnglish
Article number118184
Pages (from-to)1-10
Number of pages10
JournalLIFE SCIENCES
Volume259
DOIs
Publication statusPublished - 15 Oct 2020
MoE publication typeA2 Review article in a scientific journal

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