Projects per year
Abstract
One of the major challenges for in vivo electrochemical measurements of dopamine (DA) is to achieve selectivity in the presence of interferents, such as ascorbic acid (AA) and uric acid (UA). Complicated multimaterial structures and ill-defined pretreatments have been frequently utilized to enhance selectivity. The lack of control over the realized structures has prevented establishing associations between the achieved selectivity and the electrode structure. Owing to their easily tailorable structure, carbon nanofiber (CNF) electrodes have become promising materials for neurobiological applications. Here, a novel yet simple strategy to control the sensitivity and selectivity of CNF electrodes toward DA is reported. It consists of adjusting the lengths of CNF by modulating the growth phase during the fabrication process while keeping the surface chemistries similar. It was observed that the sensitivity of the CNF electrodes toward DA was enhanced with the increase in the fiber lengths. More importantly, the increase in the fiber length induced (i) an anodic shift in the DA oxidation peak and (ii) a cathodic shift in the AA oxidation peak. As the UA oxidation peak remained unaffected at high anodic potentials, the electrodes with long CNFs showed excellent selectivity. Electrodes without proper fibers showed only a single broad peak in the solution of AA, DA, and UA, completely lacking the ability to discriminate DA. Hence, the simple strategy of controlling CNF length without the need to carry out any complex chemical treatments provides us a feasible and robust route to fabricate electrode materials for neurotransmitter detection with excellent sensitivity and selectivity.
Original language | English |
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Pages (from-to) | 2983-2991 |
Number of pages | 9 |
Journal | Analytical Chemistry |
Volume | 95 |
Issue number | 5 |
Early online date | 2022 |
DOIs | |
Publication status | Published - 7 Feb 2023 |
MoE publication type | A1 Journal article-refereed |
Fingerprint
Dive into the research topics of 'Modulating the Geometry of the Carbon Nanofiber Electrodes Provides Control over Dopamine Sensor Performance'. Together they form a unique fingerprint.-
CONNECT: Connecting neural networks: Nervous-system-on-Chip Technology
01/12/2018 → 30/06/2024
Project: EU: Framework programmes funding
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CICLAW: Carbon Interface Connecting Living and Artificial Worlds
01/09/2019 → 31/12/2021
Project: Academy of Finland: Other research funding
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CICLAW: Carbon Interface Connecting Living and Artificial Worlds
Peltola, E., Aarva, A. & Pande, I.
01/09/2019 → 31/12/2021
Project: Academy of Finland: Other research funding
Press/Media
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Aalto University Reports Findings in Nanofibers (Modulating the Geometry of the Carbon Nanofiber Electrodes Provides Control over Dopamine Sensor Performance)
Emilia Peltola, Jani Sainio & Tomi Laurila
06/02/2023
1 item of Media coverage
Press/Media: Media appearance