Modelling of ceramide interactions with porous graphite carbon in non-aqueous liquid chromatography

C. West; Geraldine Cilpa; K. Gaudin; P. Chaminade; E. Lesellier

doi:10.1016/j.chroma.2005.03.026

Modelling of ceramide interactions with porous graphite carbon in non-aqueous liquid chromatography

C. West, Geraldine Cilpa, K. Gaudin, P. Chaminade, E. Lesellier^*

^*Corresponding author for this work

Not published at Aalto University

Université Paris-Sud

Research output: Contribution to journal › Article › Scientific › peer-review

8 Citations (Scopus)

Abstract

Interactions of solutes on porous graphitic carbon (PGC) with non-aqueous mobile phases are studied by the linear solvation energy relationship (LSER). Studies have been carried out with eight binary mixtures composed of a weak solvent (acetonitrile or methanol) and a strong solvent (tetrahydrofuran, n-butanol, CH₂Cl₂, 1,1,2-trichloro-2,2,1-trifluoroethane). The systematic analysis of a set of test compounds was performed for each solvent mixture in isocratic mode (50:50). The results were compared to those obtained on PGC with hydro-organic liquids and supercritical fluids. They were then correlated with the observed retention behaviour of lipid compounds, more particularly ceramides.

Original language	English
Pages (from-to)	77-85
Number of pages	9
Journal	Journal of Chromatography A
Volume	1087
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2005.03.026
Publication status	Published - 16 Sept 2005
MoE publication type	A1 Journal article-refereed

Keywords

Ceramides
Linear solvation energy relationship (LSER)
Non-aqueous reversed-phase liquid chromatography (NARP-LC)
Porous graphitic carbon (PGC)

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10.1016/j.chroma.2005.03.026

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abstract = "Interactions of solutes on porous graphitic carbon (PGC) with non-aqueous mobile phases are studied by the linear solvation energy relationship (LSER). Studies have been carried out with eight binary mixtures composed of a weak solvent (acetonitrile or methanol) and a strong solvent (tetrahydrofuran, n-butanol, CH2Cl2, 1,1,2-trichloro-2,2,1-trifluoroethane). The systematic analysis of a set of test compounds was performed for each solvent mixture in isocratic mode (50:50). The results were compared to those obtained on PGC with hydro-organic liquids and supercritical fluids. They were then correlated with the observed retention behaviour of lipid compounds, more particularly ceramides.",

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AU - West, C.

AU - Cilpa, Geraldine

AU - Gaudin, K.

AU - Chaminade, P.

AU - Lesellier, E.

PY - 2005/9/16

Y1 - 2005/9/16

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KW - Non-aqueous reversed-phase liquid chromatography (NARP-LC)

KW - Porous graphitic carbon (PGC)

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Modelling of ceramide interactions with porous graphite carbon in non-aqueous liquid chromatography

Abstract

Keywords

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