Model self-assembling arginine-based tripeptides show selective activity against: Pseudomonas bacteria

Valeria Castelletto, Charlotte J.C. Edwards-Gayle, Ian W. Hamley*, Glyn Barrett, Jani Seitsonen, Janne Ruokolainen, Lucas Rodrigues De Mello, Emerson Rodrigo Da Silva

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.

Original languageEnglish
Pages (from-to)615-618
Number of pages4
JournalChemical Communications
Volume56
Issue number4
DOIs
Publication statusPublished - 1 Jan 2020
MoE publication typeA1 Journal article-refereed

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