Model self-assembling arginine-based tripeptides show selective activity against: Pseudomonas bacteria

Valeria Castelletto; Charlotte J.C. Edwards-Gayle; Ian W. Hamley; Glyn Barrett; Jani Seitsonen; Janne Ruokolainen; Lucas Rodrigues De Mello; Emerson Rodrigo Da Silva

doi:10.1039/c9cc07257h

Model self-assembling arginine-based tripeptides show selective activity against: Pseudomonas bacteria

Valeria Castelletto, Charlotte J.C. Edwards-Gayle, Ian W. Hamley^*, Glyn Barrett, Jani Seitsonen, Janne Ruokolainen, Lucas Rodrigues De Mello, Emerson Rodrigo Da Silva

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

1 Citation (Scopus)

Abstract

Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.

Original language	English
Pages (from-to)	615-618
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	4
DOIs	https://doi.org/10.1039/c9cc07257h
Publication status	Published - 1 Jan 2020
MoE publication type	A1 Journal article-refereed

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10.1039/c9cc07257h

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Castelletto, V., Edwards-Gayle, C. J. C., Hamley, I. W., Barrett, G., Seitsonen, J., Ruokolainen, J., ... Da Silva, E. R. (2020). Model self-assembling arginine-based tripeptides show selective activity against: Pseudomonas bacteria. Chemical Communications, 56(4), 615-618. https://doi.org/10.1039/c9cc07257h

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abstract = "Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.",

author = "Valeria Castelletto and Edwards-Gayle, {Charlotte J.C.} and Hamley, {Ian W.} and Glyn Barrett and Jani Seitsonen and Janne Ruokolainen and {De Mello}, {Lucas Rodrigues} and {Da Silva}, {Emerson Rodrigo}",

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Model self-assembling arginine-based tripeptides show selective activity against : Pseudomonas bacteria. / Castelletto, Valeria; Edwards-Gayle, Charlotte J.C.; Hamley, Ian W.; Barrett, Glyn; Seitsonen, Jani ; Ruokolainen, Janne; De Mello, Lucas Rodrigues; Da Silva, Emerson Rodrigo.

In: Chemical Communications, Vol. 56, No. 4, 01.01.2020, p. 615-618.

Research output: Contribution to journal › Article › Scientific › peer-review

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