TY - JOUR
T1 - Model self-assembling arginine-based tripeptides show selective activity against
T2 - Pseudomonas bacteria
AU - Castelletto, Valeria
AU - Edwards-Gayle, Charlotte J.C.
AU - Hamley, Ian W.
AU - Barrett, Glyn
AU - Seitsonen, Jani
AU - Ruokolainen, Janne
AU - De Mello, Lucas Rodrigues
AU - Da Silva, Emerson Rodrigo
PY - 2020/1/14
Y1 - 2020/1/14
N2 - Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.
AB - Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.
UR - http://www.scopus.com/inward/record.url?scp=85077727321&partnerID=8YFLogxK
U2 - 10.1039/c9cc07257h
DO - 10.1039/c9cc07257h
M3 - Article
C2 - 31833497
AN - SCOPUS:85077727321
SN - 1359-7345
VL - 56
SP - 615
EP - 618
JO - Chemical Communications
JF - Chemical Communications
IS - 4
ER -