Mixture of epsiloncaprolactone-lactide copolymer and tricalcium phosphate: a histological and immunohistochemical study of tissue reactions: A histological and immunohistochemical study of tissue reactions

M. Ekholm, J. Hietanen, C. Lindqvist, J. Rautavuori, S. Santavirta, A. Salo, J. Seppälä, R. Suuronen

    Research output: Contribution to journalArticleScientificpeer-review

    8 Citations (Scopus)

    Abstract

    In cranio-maxillofacial surgery, bone transplantation is needed for treatment of bony defects. An autograft, allograft or biomaterial can be used. Autogenous bone grafts are considered to be the best materials available, but there are some disadvantages in their use including donorsite morbidity, need for a second operative site and limited graft supply. A search for new bone-graft materials therefore remains necessary. We prepared a mixture of tricalcium phosphate (TCP), which is a resorbable, non-toxic, osteoconductive ceramic material and ε-caprolactone-lactide copolymer P(ε-CL/DL-LA), a resorbable polymer, and placed it in the dermis and in mandibular bone defects in 13 rabbits. Follow-up times were two, three, seven, eight, 12, 15 and 18 weeks, tissue reactions were assessed, histologically and immunohistochemically. Times of resorption of the material from tissues were reported. We found that the mixture caused a mild inflammatory reaction when placed in bone and severe inflammation when placed in dermis. No highly fluorescent layer of tenascin or fibronectin was found surrounding the implant area. The mixture was excellent to handle and very easy to place into bone defects. The results are promising and have led us to continue development of the mixture.
    Original languageEnglish
    Pages (from-to)69-74
    Number of pages6
    JournalJournal of Materials Science: Materials in Medicine
    Volume10
    Issue number2
    DOIs
    Publication statusPublished - 1999
    MoE publication typeA1 Journal article-refereed

    Keywords

    • autogenous bone grafts
    • bone transplantation
    • resorbable polymer

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