Mild Traumatic Brain Injury Affects Cognitive Processing and Modifies Oscillatory Brain Activity during Attentional Tasks

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Mild Traumatic Brain Injury Affects Cognitive Processing and Modifies Oscillatory Brain Activity during Attentional Tasks. / Kaltiainen, Hanna; Liljestrom, Mia; Helle, Liisa; Salo, Anne; Hietanen, Marja; Renvall, Hanna; Forss, Nina.

In: JOURNAL OF NEUROTRAUMA, Vol. 36, No. 14, 15.07.2019, p. 2222-2232.

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@article{b516e8c7bd274d988abf1816cd0eef3b,
title = "Mild Traumatic Brain Injury Affects Cognitive Processing and Modifies Oscillatory Brain Activity during Attentional Tasks",
abstract = "Despite the high prevalence of mild traumatic brain injury (mTBI), current diagnostic tools to objectively assess cognitive complaints after mTBI continue to be inadequate. Our aim was to identify neuronal correlates for cognitive difficulties in mTBI patients by evaluating the possible alterations in oscillatory brain activity during a behavioral task known to be sensitive to cognitive impairment after mTBI. We compared oscillatory brain activity during rest and cognitive tasks (Paced Auditory Serial Addition Test [PASAT] and a vigilance test [VT]) with magnetoencephalography between 25 mTBI patients and 20 healthy controls. Whereas VT induced no significant differences compared with resting state in either group, patients exhibited stronger attenuation of 8-to 14-Hz oscillatory activity during PASAT than healthy controls in the left parietotemporal cortex (p ≤ 0.05). Further, significant task-related modulation in the left superior frontal gyrus and right prefrontal cortex was detected only in patients. The ∼10-Hz (alpha) peak frequency declined in frontal, temporal, and parietal regions during PASAT compared with rest (p < 0.016) in patients, whereas in controls it remained the same or showed a tendency to increase. In patients, the ∼10-Hz peak amplitude was negatively correlated with behavioral performance in the Trail Making Test. The observed alterations in the cortical oscillatory activity during cognitive load may provide measurable neurophysiological correlates of cognitive difficulties in mTBI patients, even at the individual level.",
keywords = "alpha frequency modulation, cognitive task, magnetoencephalography, mild traumatic brain injury, SERIAL ADDITION TEST, MINOR HEAD-INJURY, TEST-RETEST RELIABILITY, INTRAINDIVIDUAL VARIABILITY, SUSTAINED ATTENTION, ALPHA-ACTIVITY, EEG SPECTRA, MEMORY, LOCALIZATION, PERFORMANCE",
author = "Hanna Kaltiainen and Mia Liljestrom and Liisa Helle and Anne Salo and Marja Hietanen and Hanna Renvall and Nina Forss",
year = "2019",
month = "7",
day = "15",
doi = "10.1089/neu.2018.6306",
language = "English",
volume = "36",
pages = "2222--2232",
journal = "JOURNAL OF NEUROTRAUMA",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "14",

}

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TY - JOUR

T1 - Mild Traumatic Brain Injury Affects Cognitive Processing and Modifies Oscillatory Brain Activity during Attentional Tasks

AU - Kaltiainen, Hanna

AU - Liljestrom, Mia

AU - Helle, Liisa

AU - Salo, Anne

AU - Hietanen, Marja

AU - Renvall, Hanna

AU - Forss, Nina

PY - 2019/7/15

Y1 - 2019/7/15

N2 - Despite the high prevalence of mild traumatic brain injury (mTBI), current diagnostic tools to objectively assess cognitive complaints after mTBI continue to be inadequate. Our aim was to identify neuronal correlates for cognitive difficulties in mTBI patients by evaluating the possible alterations in oscillatory brain activity during a behavioral task known to be sensitive to cognitive impairment after mTBI. We compared oscillatory brain activity during rest and cognitive tasks (Paced Auditory Serial Addition Test [PASAT] and a vigilance test [VT]) with magnetoencephalography between 25 mTBI patients and 20 healthy controls. Whereas VT induced no significant differences compared with resting state in either group, patients exhibited stronger attenuation of 8-to 14-Hz oscillatory activity during PASAT than healthy controls in the left parietotemporal cortex (p ≤ 0.05). Further, significant task-related modulation in the left superior frontal gyrus and right prefrontal cortex was detected only in patients. The ∼10-Hz (alpha) peak frequency declined in frontal, temporal, and parietal regions during PASAT compared with rest (p < 0.016) in patients, whereas in controls it remained the same or showed a tendency to increase. In patients, the ∼10-Hz peak amplitude was negatively correlated with behavioral performance in the Trail Making Test. The observed alterations in the cortical oscillatory activity during cognitive load may provide measurable neurophysiological correlates of cognitive difficulties in mTBI patients, even at the individual level.

AB - Despite the high prevalence of mild traumatic brain injury (mTBI), current diagnostic tools to objectively assess cognitive complaints after mTBI continue to be inadequate. Our aim was to identify neuronal correlates for cognitive difficulties in mTBI patients by evaluating the possible alterations in oscillatory brain activity during a behavioral task known to be sensitive to cognitive impairment after mTBI. We compared oscillatory brain activity during rest and cognitive tasks (Paced Auditory Serial Addition Test [PASAT] and a vigilance test [VT]) with magnetoencephalography between 25 mTBI patients and 20 healthy controls. Whereas VT induced no significant differences compared with resting state in either group, patients exhibited stronger attenuation of 8-to 14-Hz oscillatory activity during PASAT than healthy controls in the left parietotemporal cortex (p ≤ 0.05). Further, significant task-related modulation in the left superior frontal gyrus and right prefrontal cortex was detected only in patients. The ∼10-Hz (alpha) peak frequency declined in frontal, temporal, and parietal regions during PASAT compared with rest (p < 0.016) in patients, whereas in controls it remained the same or showed a tendency to increase. In patients, the ∼10-Hz peak amplitude was negatively correlated with behavioral performance in the Trail Making Test. The observed alterations in the cortical oscillatory activity during cognitive load may provide measurable neurophysiological correlates of cognitive difficulties in mTBI patients, even at the individual level.

KW - alpha frequency modulation

KW - cognitive task

KW - magnetoencephalography

KW - mild traumatic brain injury

KW - SERIAL ADDITION TEST

KW - MINOR HEAD-INJURY

KW - TEST-RETEST RELIABILITY

KW - INTRAINDIVIDUAL VARIABILITY

KW - SUSTAINED ATTENTION

KW - ALPHA-ACTIVITY

KW - EEG SPECTRA

KW - MEMORY

KW - LOCALIZATION

KW - PERFORMANCE

UR - http://www.scopus.com/inward/record.url?scp=85068528487&partnerID=8YFLogxK

U2 - 10.1089/neu.2018.6306

DO - 10.1089/neu.2018.6306

M3 - Article

VL - 36

SP - 2222

EP - 2232

JO - JOURNAL OF NEUROTRAUMA

JF - JOURNAL OF NEUROTRAUMA

SN - 0897-7151

IS - 14

ER -

ID: 33659667