Mild Traumatic Brain Injury Affects Cognitive Processing and Modifies Oscillatory Brain Activity during Attentional Tasks

Research output: Contribution to journalArticleScientificpeer-review

Researchers

Research units

  • MEGIN Elekta Oy
  • Lohja District Hospital
  • University of Helsinki
  • Helsinki University Central Hospital

Abstract

Despite the high prevalence of mild traumatic brain injury (mTBI), current diagnostic tools to objectively assess cognitive complaints after mTBI continue to be inadequate. Our aim was to identify neuronal correlates for cognitive difficulties in mTBI patients by evaluating the possible alterations in oscillatory brain activity during a behavioral task known to be sensitive to cognitive impairment after mTBI. We compared oscillatory brain activity during rest and cognitive tasks (Paced Auditory Serial Addition Test [PASAT] and a vigilance test [VT]) with magnetoencephalography between 25 mTBI patients and 20 healthy controls. Whereas VT induced no significant differences compared with resting state in either group, patients exhibited stronger attenuation of 8-to 14-Hz oscillatory activity during PASAT than healthy controls in the left parietotemporal cortex (p ≤ 0.05). Further, significant task-related modulation in the left superior frontal gyrus and right prefrontal cortex was detected only in patients. The ∼10-Hz (alpha) peak frequency declined in frontal, temporal, and parietal regions during PASAT compared with rest (p < 0.016) in patients, whereas in controls it remained the same or showed a tendency to increase. In patients, the ∼10-Hz peak amplitude was negatively correlated with behavioral performance in the Trail Making Test. The observed alterations in the cortical oscillatory activity during cognitive load may provide measurable neurophysiological correlates of cognitive difficulties in mTBI patients, even at the individual level.

Details

Original languageEnglish
Pages (from-to)2222-2232
Number of pages11
JournalJOURNAL OF NEUROTRAUMA
Volume36
Issue number14
Early online date10 Apr 2019
Publication statusPublished - 15 Jul 2019
MoE publication typeA1 Journal article-refereed

    Research areas

  • alpha frequency modulation, cognitive task, magnetoencephalography, mild traumatic brain injury, SERIAL ADDITION TEST, MINOR HEAD-INJURY, TEST-RETEST RELIABILITY, INTRAINDIVIDUAL VARIABILITY, SUSTAINED ATTENTION, ALPHA-ACTIVITY, EEG SPECTRA, MEMORY, LOCALIZATION, PERFORMANCE

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